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  1. Efficacy and Safety of Tolvaptan in Subjects With Chronic Kidney Disease Between Late Stage 2 to Early Stage 4 Due to Autosomal Dominant Polycystic Kidney Disease - Mayo Clinic

    About this study. The purpose of the study is to determine whether tolvaptan is effective and safe for the treatment of late-stage chronic kidney disease ...

  2. Modulation of Heme Oxygenase 1 by Nizatidine and Lisinopril in Healthy Subjects - Mayo Clinic

    About this study. To assess if oral nizatidine or lisinopril alone and in combination will increase heme oxygenase 1 (HO-1) protein concentration and ...

  3. My Pathway: A Study Evaluating Herceptin/Perjeta, Tarceva, Zelboraf/Cotellic, Erivedge, Alecensa, and Tecentriq Treatment Targeted Against Certain Molecular Alterations in Participants With Advanced Solid Tumors - Mayo Clinic

    This multicenter, non-randomized, open-label study will evaluate the efficacy and safety of six treatment regimens in participants with advanced solid tumors ...

  4. Carfilzomib and Melphalan Before Stem Cell Transplant in Treating Patients With Multiple Myeloma - Mayo Clinic

    Carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as melphalan, work in ...

  5. A Study of the Long-Term Safety of Tafamidis for Patients with Transthyretin Cardiomyopathy - Mayo Clinic

    The purpose of this study is to evaluate the long-term safety of tafamidis meglumine for treating patients who have either the genetic variants or wild-type ...

  6. Ixabepilone and Temsirolimus in Treating Patients with Solid Tumors that are Metastatic or Cannot ce Removed by Surgery - Mayo Clinic

    Temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving ixabepilone together with temsirolimus may kill ...

  7. Gut Permeability Assessment in Celiac and Gluten Sensitive Children - Mayo Clinic

    This study will assess the effect of gluten on gut barrier function. Investigators at the Mayo Clinic have developed a new gut permeability test using rhamnose ...

  8. A Study to Assess the Effectiveness and Safety of Apremilast in Pediatric Patients (6 through 17 years old) with Moderate-to-Severe Plaque Psoriasis - Mayo Clinic

    The primary purpose of this study is to evaluate the clinical effectiveness of apremilast compared with placebo in children and adolescents (ages 6 through 17 ...

  9. A Study to Evaluate Intravenous Erenumab in Patients with Status Migrainosus - Mayo Clinic

    The purpose of this study is to investigate the use of erenumab 140mg IV in patients with status migrainosus. The specific aims of the study are to evaluate ...

  10. A Study of the Effectiveness and Safety of Mepolizumab as Adjunctive Therapy in Participants with Severe Eosinophilic Asthma - Mayo Clinic

    The purpose of this study is to evaluate the effectiveness and safety of mepolizumab adjunctive therapy in participants with severe eosinophilic asthma by ...