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  1. Pazopanib in Treating Patients with Metastatic Non-Clear Cell Kidney Cancer - Mayo Clinic

    Pazopanib hydrochloride may also stop the growth of kidney cancer by blocking blood flow to the tumor. Participation eligibility. Participant eligibility ...

  2. Transfemoral Replacement of Aortic Valve With HLT MeriDIAN Valve Early Feasibility Trial - Mayo Clinic

    The purpose of this study is to evaluate the safety and performance of the HLT System in patients with severe aortic stenosis who present at High Risk for ...

  3. Trial of Eflornithine Plus Sulindac in Patients with Familial Adenomatous Polyposis (FAP) - Mayo Clinic

    This includes: 1) FAP related disease progression indicating the need for excisional intervention involving the colon, rectum, pouch, duodenum and/or 2) ...

  4. A Study to Evaluate a Standard-dose and High- dose Regimen of Encorafenib + Binimetinib in Patients with BRAFV600-mutant Melanoma Brain Metastasis - Mayo Clinic

    The purpose of this study is to assess the safety, effectiveness and pharmacokinetic (PK) of 2 dosing regimens of encorafenib + binimetinib combination in ...

  5. Anetumab Ravtansine and Atezolizumab in Treating Participants With Advanced Non-small Cell Lung Cancer - Mayo Clinic

    Monoclonal antibodies, such as anetumab ravtansine and atezolizumab, may interfere with the ability of tumor cells to grow and spread. Participation eligibility.

  6. Mirikizumab in the Treatment of Chronic Inflammatory Conditions of the Pouch - Mayo Clinic

    About this study. The goal of this clinical trial is to learn if mirikizumab works to treat pouch disorders in adults. The main questions it aims to answer ...

  7. A Study of Pembrolizumab (MK-3475) Versus Placebo in Combination with Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer - Mayo Clinic

    A Study of Pembrolizumab (MK-3475) Versus Placebo in Combination with Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage ...

  8. Bioequivalence & Food Effect Study in Patients With Solid Tumor or Hematologic Malignancies - Mayo Clinic

    Subjects must not be eligible for therapy of higher curative potential where an alternative treatment has been shown to prolong survival in an analogous ...

  9. Early Feasibility Study of the Edwards FORMA Tricuspid Transcatheter Repair System - Mayo Clinic

    About this study. The study is a multi-center, prospective, early feasibility study to measure individual patient clinical outcomes and effectiveness, ...

  10. A Study Comparing the Effectiveness and Safety of Combining Three versus Two Oral Treatments for the Initial Therapy of Patients who have Newly Diagnosed Hypertension of the Pulmonary Artery - Mayo Clinic

    The purpose of this study is to compare the effectiveness and safety of three (macitentan, tadalafil, and selexipag) versus two (macitentan and tadalafil) oral ...