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  1. Study of INCB053914 in Subjects With Advanced Malignancies - Mayo Clinic

    About this study. This is an open-label, dose-escalation study of the proviral integration site of Moloney murine leukemia virus (PIM) kinase inhibitor ...

  2. A Study to Evaluate the Combination of Binimetinib and Palbociclib in Treating Patients with KRAS and NRAS Mutant Metastatic or Unresectable Colorectal Cancer - Mayo Clinic

    Binimetinib and palbociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as TAS- ...

  3. RLY-2608-201-Ph2 Study of RLY-2608 in PROS and PIK3CA Driven Malformations - Mayo Clinic

    About this study. The purpose of this study is to compare the efficacy and safety of RLY-2608 versus placebo in adult, adolescent, and pediatric ...

  4. A Study to Evaluate the Effectiveness and Safety of Vibegron Administered Orally for 12 Weeks to Women with Irritable Bowel Syndrome - Mayo Clinic

    The purpose of this study is to evaluate the effectiveness and safety of vibegron, a beta-3 adrenergic receptor (β3-AR) agonist, in the treatment of pain ...

  5. A Study to Evaluate Home Monitoring of Post-Discharge Congestive Heart Failure Patients - Mayo Clinic

    About this study. The primary purpose of this study is to collect long-term (2-month duration) data with the ADI CHF Device on patients at home to ...

  6. A Study to Evaluate Effectiveness of 2 Doses of Oral CXA-10 in Pulmonary Arterial Hypertension (PAH) - Mayo Clinic

    The purpose of this study is to evaluate the safety, effectiveness and pharmacokinetics of 2 doses of CXA-10 on stable background therapy in 96 subjects 18 to ...

  7. Combination Chemotherapy and Surgery in Treating Young Patients with Wilms Tumor - Mayo Clinic

    This phase III clinical trial is studying how well combination chemotherapy and surgery work in treating young patients with Bilateral Wilms tumor and children ...

  8. A Study of SC‑004 in Subjects With Advanced Solid Tumors - Mayo Clinic

    Part A (dose regimen finding) will allow definition of the maximum tolerated dose (MTD) through dose escalation and possible dose interval modification. In Part ...

  9. Study To Assess The Efficacy, Safety, And Tolerability Of NOC-110 In Adults With Refractory Or Unexplained Chronic Cough - Mayo Clinic

    This is a phase 2b, randomized, double-blind, placebo-controlled study investigating the efficacy, safety, and tolerability of Taplucainium Inhalation Powder ( ...

  10. Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS - Mayo Clinic

    Other important efficacy measures include time to respiratory events, clinical global impression (CGI), assessment of dyspnea using the Borg scale and sleep ...