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  1. A Study of Momelotinib Versus Danazol in Symptomatic and Anemic Myelofibrosis Patients - Mayo Clinic

    Subjects randomized to receive DAN who are receiving clinical benefit at the end of Week 24 may choose to continue DAN therapy up to Week 48. The comparator ...

  2. A Study of Mavacamten in Patients with Hypertrophic Cardiomyopathy Who Have Completed the MAVERICK-HCM or EXPLORER-HCM Trials - Mayo Clinic

    The purpose of this study is to assess the long-term safety and tolerability of mavacamten in participants with hypertrophic cardiomyopathy (HCM) previously ...

  3. A Study of Apalutamide (ARN-509) in Men With Non-Metastatic Castration-Resistant Prostate Cancer - Mayo Clinic

    The purpose of this study is to evaluate the efficacy and safety of apalutamide in adult men with high-risk non-metastatic castration-resistant prostate cancer.

  4. Pembrolizumab, Combination Chemotherapy, and Radiation Therapy Before Surgery in Treating Adult Patients With Locally Advanced Gastroesophageal Junction or Gastric Cardia Cancer That Can Be Removed by Surgery - Mayo Clinic

    Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Giving pembrolizumab, combination chemotherapy, and radiation therapy before ...

  5. Sirolimus, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients At High Risk for Cholangiocarcinoma Recurrence After Liver Transplant or Surgery - Mayo Clinic

    Sirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as gemcitabine ...

  6. A Study to Assess Effectiveness and Safety of SER‑287 in Adults With Active Mild-to-Moderate Ulcerative Colitis - Mayo Clinic

    Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and ...

  7. Sapanisertib in Treating Patients With Relapsed and/or Refractory Acute Lymphoblastic Leukemia - Mayo Clinic

    About this study. This phase II trial studies how well sapanisertib works in treating patients with acute lymphoblastic leukemia that has returned after a ...

  8. Nilotinib and Combination Chemotherapy in Treating Patients with Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia or Blastic Phase Chronic Myelogenous Leukemia - Mayo Clinic

    About this study. In this study researchers want to find out more about the side effects of a new drug for Philadelphia chromosome-positive (Ph+) acute ...

  9. Vaccine Therapy With Bevacizumab Versus Bevacizumab Alone in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery - Mayo Clinic

    Vaccines consisting of heat shock protein-peptide complexes made from a person's own tumor tissue may help the body build an effective immune response to kill ...

  10. Pazopanib Hydrochloride in Treating Patients With Progressive Carcinoid Tumors - Mayo Clinic

    About this study. This randomized phase II trial studies how well pazopanib hydrochloride works in treating patients with carcinoid tumors that are growing, ...