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  1. A Study to Test the Effect of BI 456906 on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT) - Mayo Clinic

    The purpose of this trial is to evaluate the effect of treatment with BI 456906 3.6 and 6.0 mg once weekly versus (vs.) placebo on cardiovascular (CV) safety as ...

  2. Efficacy and Safety of Treatment With Alpelisib Plus Endocrine Therapy in Patients With HR+, HER2-negative aBC, With PIK3CA Mutations, Whose Disease Has Progressed on or After CDK 4/6 Treatment With an Aromatase Inhibitor (AI) or Fulvestrant - Mayo Clinic

    Efficacy and Safety of Treatment With Alpelisib Plus Endocrine Therapy in Patients With HR+, HER2-negative aBC, With PIK3CA Mutations, Whose Disease Has ...

  3. A Study of Mavacamten in Patients with Hypertrophic Cardiomyopathy Who Have Completed the MAVERICK-HCM or EXPLORER-HCM Trials - Mayo Clinic

    The purpose of this study is to assess the long-term safety and tolerability of mavacamten in participants with hypertrophic cardiomyopathy (HCM) previously ...

  4. NEURO-TTRansform: A Study to Evaluate the Efficacy and Safety of AKCEA-TTR-LRx in Participants With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy - Mayo Clinic

    Neuropathy Symptom and Change Score (NSC); Physical component summary (PCS) score of 36-Item Short Form Survey (SF-36); Polyneuropathy disability (PND) score ...

  5. Erlotinib Hydrochloride in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Completely Removed by Surgery (An ALCHEMIST Treatment Trial) - Mayo Clinic

    Erlotinib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Participation eligibility. Participant ...

  6. Combination Chemotherapy and Surgery in Treating Young Patients with Wilms Tumor - Mayo Clinic

    This phase III clinical trial is studying how well combination chemotherapy and surgery work in treating young patients with Bilateral Wilms tumor and children ...

  7. Anetumab Ravtansine and Atezolizumab in Treating Participants With Advanced Non-small Cell Lung Cancer - Mayo Clinic

    Monoclonal antibodies, such as anetumab ravtansine and atezolizumab, may interfere with the ability of tumor cells to grow and spread. Participation eligibility.

  8. A Study Evaluating the Effectiveness and Safety of Axicabtagene Ciloleucel in Subjects with High-Risk Large B-Cell Lymphoma - Mayo Clinic

    Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and ...

  9. Nilotinib and Combination Chemotherapy in Treating Patients with Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia or Blastic Phase Chronic Myelogenous Leukemia - Mayo Clinic

    About this study. In this study researchers want to find out more about the side effects of a new drug for Philadelphia chromosome-positive (Ph+) acute ...

  10. Investigational Device Evaluation of the WATCHMAN FLX™ LAA Closure Technology - Mayo Clinic

    About this study. The study is a prospective, non-randomized, multi-center investigation to establish the safety and effectiveness of the WATCHMAN FLX™ Left ...