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  1. Circulating NEP and NEP Inhibition Study in Heart Failure With Preserved Ejection Fraction - Mayo Clinic

    To determine biomarker responses to Entresto™in patients with Heart Failure with preserved Ejection Fraction (HFpEF) and who have high or low serum neprilysin ( ...

  2. Cediranib Maleate and Selumetinib in Treating Patients With Solid Malignancies - Mayo Clinic

    Cediranib maleate and selumetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Cediranib maleate may also stop the ...

  3. Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C Melanoma Patients

    The purpose of this study is to demonstrate that a neoadjuvant Daromun treatment followed by surgery and adjuvant therapy improves in a statistically ...

  4. Double Cord Versus Haploidentical (Blood and Marrow Transplant Clinical Trials Network #1101)

    About this study. Hematopoietic cell transplants (HCT) are one treatment option for people with leukemia or lymphoma. Family members, unrelated donors or ...

  5. A Study to Evaluate Glucagon Ready to Use (RTU) in Subjects With Hyperinsulinemic Hypoglycemia After Bariatric Surgery - Mayo Clinic

    Subjects will be randomly assigned to either Glucagon RTU or Placebo for the duration of a 12-week Outpatient Stage. A follow-up safety assessment visit will ...

  6. Study Evaluating the Safety, Tolerability, and Effectiveness of EDP-305 in Subjects with Nonalcoholic Steatohepatitis (NASH) - Mayo Clinic

    The purpose of this double-blind study is to obtain the most unbiased assessment of clinical safety and efficacy with the doses of EDP-305 being studied.

  7. Avatrombopag for the Treatment of Thrombocytopenia in Adults Scheduled for a Surgical Procedure - Mayo Clinic

    About this study. Phase 3b open-label, multicenter study to evaluate the safety and efficacy of avatrombopag in subjects with thrombocytopenia scheduled for ...

  8. Early Feasibility Study of HyperQureTM RDN System, Laparoscopic Renal Denervation Therapy, in Patients With Resistant Hypertension - Mayo Clinic

    Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and ...

  9. Venetoclax and Vincristine Liposomal in Treating Patients With Relapsed or Refractory T-cell or B-cell Acute Lymphoblastic Leukemia - Mayo Clinic

    Venetoclax may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as vincristine liposomal ...

  10. Androgen Deprivation to Enrich PSMA Expression and Improve Sensitivity of Staging PSMA PET/C - Mayo Clinic

    The purpose of this study is for the comparison of SUVmax and SUVmean values of the dominate primary prostate lesion between pre and post ADT imaging using ...