Daniel M. Trifiletti, M.D.

Dr. Dan Trifiletti is Professor of Radiation Oncology at Mayo Clinic in Jacksonville, Florida, specializing in the treatment of primary and metastatic brain tumors, spinal tumors and other complex neurologic conditions.

He provides advanced, individualized cancer care using leading-edge radiation therapies, with expertise in stereotactic radiosurgery (SRS), proton therapy, image-guided radiation therapy (IGRT) and intensity-modulated radiation therapy (IMRT).

Dr. Trifiletti is committed to combining precision radiation oncology with the latest advances in cancer research to deliver personalized treatment plans that maximize effectiveness while minimizing treatment-related side effects. He works closely with multidisciplinary teams to ensure patients have access to innovative therapies, including clinical trials and emerging treatment approaches when appropriate.

His clinical practice is centered on patient education, shared decision-making and helping individuals understand the full range of available treatment options. By taking time to understand each patient's goals, values and concerns, Dr. Trifiletti partners with patients and their families to develop care plans that support both optimal clinical outcomes and quality of life.

In addition to his clinical practice, Dr. Trifiletti is dedicated to advancing the field of radiation oncology through research, education and the integration of innovative technologies into routine patient care.

"I want to connect patients with new treatment opportunities that they weren't aware of, to ultimately help them make the best decision for themselves," says Dr. Trifiletti.

Outside of work, he enjoys spending time with his four daughters, cooking and enjoying outdoor adventures.