Rocuronium (intravenous route)

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of rocuronium injection in children. However, use of this medicine in children for rapid sequence intubation is not recommended.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rocuronium injection in the elderly. However, elderly patients are more likely to have residual neuromuscular block or blood circulation problems, which may require caution in patients receiving this medicine.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amikacin
• Bacitracin
• Capreomycin
• Carbamazepine
• Colistimethate Sodium
• Dibekacin
• Epinephrine
• Fosphenytoin
• Framycetin
• Gentamicin
• Isepamicin
• Isoflurane
• Kanamycin
• Neomycin
• Netilmicin
• Phenytoin
• Polymyxin B
• Procainamide
• St John's Wort
• Streptomycin
• Tobramycin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Enflurane
• Magnesium
• Sevoflurane

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Blood circulation problems or
• Eaton-Lambert syndrome (muscle problem) or
• Electrolyte imbalance or
• Heart or blood vessel disease or
• Heart rhythm problem (eg, QT prolongation) or
• Heart valve disease or
• Metabolic acidosis or alkalosis or
• Myasthenia gravis (muscle problem) or
• Pulmonary hypertension—Use with caution. May make these conditions worse.

• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

• Malignant hyperthermia—Should be treated first before using this medicine.

Rare

• Cough
• difficulty with breathing
• dizziness
• fainting
• fast, slow, or irregular heartbeat
• noisy breathing
• swelling at the injection site
• tightness in the chest

Incidence not known

• Difficulty with swallowing
• hives, itching, or skin rash
• muscular pain, tenderness, wasting, or weakness
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• unusual tiredness or weakness