Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

  1. Synarel


Nafarelin nasal spray is a synthetic (man-made) hormone that is similar to a natural hormone that is produced in the brain. It is used for the treatment of:

  • Central precocious puberty (CPP), a condition which causes early puberty in boys (before 9 years of age) and in girls (before 8 years of age), or
  • Endometriosis, a painful condition caused by extra tissue growing inside or outside of the uterus (womb).

When given regularly to boys and girls experiencing early puberty, nafarelin slows down the development of genital areas in both sexes. It will also slow breast development in girls. This medicine will delay puberty as long as the child continues to use it.

When given regularly to women, nafarelin decreases estrogen levels which helps treat endometriosis. It prevents the growth of tissue caused by endometriosis in adult women during treatment and for 6 months after treatment is discontinued.

Suppressing estrogen can cause thinning of the bones or slowing of growth. This is a problem for adult women whose bones are no longer growing. Slowing the growth of bones is a positive effect for girls and boys whose bones grow too fast when puberty begins too early. Boys and girls may benefit by adding inches to their adult height when nafarelin causes their bones to grow at the proper and expected rate for children.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Spray