Mannitol (intravenous route)

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of mannitol injection in children. However, children younger than 2 years of age, especially preterm and term neonates, are more likely to have fluid and electrolyte abnormalities. Safety and efficacy have been established.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of prochlorperazine in the elderly. However, elderly patients are more likely to have fluid and electrolyte imbalances and age-related kidney, heart, or lung problems, which may require caution in the dose for patients receiving this medicine.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amikacin
• Amikacin Liposome
• Arsenic Trioxide
• Droperidol
• Levomethadyl
• Sotalol
• Tobramycin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Licorice

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Anuria (cannot pass urine) or
• Hypovolemia (low blood volume), severe or
• Intracranial bleeding, active (except during craniotomy or head surgery) or
• Lung or breathing problems, severe (eg, congestion, fluid or swelling in the lungs)—Should not be used in patients with these conditions.

• Brain problems (eg, compromised blood-brain barrier) or
• Congestive heart failure or
• Kidney disease—Use with caution. May make this condition worse.

• Fluid or electrolyte imbalance—Use with caution. Must be corrected first before receiving this medicine.

Incidence not known

• Agitation
• bloating or swelling of the face, arms, hands, lower legs, or feet
• bloody or cloudy urine
• blue lips and fingernails
• blurred vision
• bulging soft spot on the head of an infant
• change in the ability to see colors, especially blue or yellow
• change in the amount or frequency of urine
• changes in skin color
• chest pain
• chills
• cloudy urine
• confusion
• cough
• coughing that sometimes produces a pink frothy sputum
• decreased awareness or responsiveness
• decreased urination
• depression
• difficult or labored breathing
• difficult, fast, or noisy breathing
• difficulty swallowing
• dilated neck veins
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• drowsiness
• dry mouth
• extreme tiredness or weakness
• fainting
• fast, irregular, pounding, or racing heartbeat or pulse
• fever
• headache
• high blood pressure
• hives, itching, skin rash
• hostility
• increase in heart rate
• increased sweating
• increased thirst
• irregular breathing
• irritability
• lightheadedness
• loss of appetite
• loss of consciousness
• mood changes
• muscle pain, cramps, tremors, or twitching
• nausea
• nervousness
• not able to pass urine
• numbness or tingling in the hands, feet, or lips pain
• pain in lower back or side
• pain, redness, or pale skin at the injection site
• pale skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• rapid weight gain
• rapid, deep breathing
• restlessness
• seizures
• severe sleepiness
• stomach cramps or pain
• sunken eyes
• tightness in the chest
• trouble sleeping
• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
• unusual weight gain or loss
• vomiting
• weakness or heaviness of the legs
• wrinkled skin

Incidence not known

• Bone or muscle stiffness
• difficulty in moving
• general feeling of discomfort or illness
• joint pain or swelling
• lack or loss of strength
• swelling or itching at the injection site