Isavuconazonium (oral route)


    Brand Name

    US Brand Name

    Cresemba


    Description

    Isavuconazonium is used to treat serious fungal or yeast infections, including invasive aspergillosis and invasive mucormycosis. This medicine works by killing the fungus or yeast and preventing its growth.

    This medicine is available only with your doctor's prescription.

    This product is available in the following dosage forms:

    • Capsule

    Before Using

    In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

    Allergies

    Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

    Pediatric

    Appropriate studies have not been performed on the relationship of age to the effects of isavuconazonium in children younger than 6 years of age weighing less than 16 kilograms (kg). Safety and efficacy have not been established.

    Geriatric

    Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of isavuconazonium in the elderly.

    Breastfeeding

    There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

    Drug Interactions

    Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

    Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

    • Apalutamide
    • Boceprevir
    • Carbamazepine
    • Ceritinib
    • Clarithromycin
    • Cobicistat
    • Enzalutamide
    • Fosphenytoin
    • Idelalisib
    • Indinavir
    • Itraconazole
    • Ivosidenib
    • Ketoconazole
    • Lonafarnib
    • Lumacaftor
    • Mephobarbital
    • Mifepristone
    • Mitotane
    • Nefazodone
    • Nelfinavir
    • Paritaprevir
    • Phenytoin
    • Posaconazole
    • Ribociclib
    • Rifampin
    • Rifapentine
    • Ritonavir
    • Saquinavir
    • St John's Wort
    • Telaprevir
    • Telithromycin
    • Troleandomycin
    • Tucatinib
    • Voriconazole

    Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

    • Adagrasib
    • Atorvastatin
    • Avacopan
    • Colchicine
    • Cyclosporine
    • Digoxin
    • Enasidenib
    • Everolimus
    • Fluconazole
    • Lopinavir
    • Mavacamten
    • Midazolam
    • Mycophenolate Mofetil
    • Mycophenolic Acid
    • Nirmatrelvir
    • Sirolimus
    • Tacrolimus
    • Tazemetostat
    • Tolvaptan
    • Vincristine

    Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

    • Bupropion

    Other Interactions

    Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

    Using this medicine with any of the following is not recommended. Your doctor may decide not to treat you with this medication, change some of the other medicines you take, or give you special instructions about the use of food, alcohol, or tobacco.

    • Grapefruit Juice

    Other Medical Problems

    The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

    • Heart rhythm problem (eg, familial short QT syndrome)—Should not be used in patients with this condition.
    • Liver disease—Use with caution. May make this condition worse.

    Proper Use

    Take this medicine for the full time of treatment, even if you begin to feel better. Also, keep your appointments with your doctor for check-ups so that your doctor will be better able to tell you when to stop taking this medicine.

    This medicine comes with a patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions.

    Swallow the capsule whole. Do not crush, break, dissolve, or open it. You may take this medicine with or without food.

    Your doctor may switch you between injection and oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

    Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

    Dosing

    The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

    The amount of medicine that you take depends on the strength of the medicine. Also,