Estradiol and medroxyprogesterone (intramuscular route)

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

This medicine can be used for birth control in teenage females and is not expected to cause different side effects or problems than it does in adults. Some teenagers may need extra information on the importance of taking this medication exactly as prescribed.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Fezolinetant
• Tranexamic Acid

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abametapir
• Amifampridine
• Amoxicillin
• Ampicillin
• Amprenavir
• Apalutamide
• Aprepitant
• Armodafinil
• Artemether
• Avacopan
• Bacampicillin
• Belzutifan
• Betamethasone
• Bexarotene
• Bosentan
• Bupropion
• Carbamazepine
• Carbenicillin
• Cefaclor
• Cefadroxil
• Cefdinir
• Cefditoren
• Cefixime
• Cefpodoxime
• Cefprozil
• Ceftazidime
• Ceftibuten
• Cefuroxime
• Cenobamate
• Ceritinib
• Clarithromycin
• Clobazam
• Cloxacillin
• Colesevelam
• Conivaptan
• Cosyntropin
• Cyclacillin
• Cyclosporine
• Dabrafenib
• Darunavir

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Atazanavir
• Diazepam
• Ginseng
• Lamotrigine
• Levothyroxine
• Licorice
• Lorazepam
• Selegiline
• Tacrine
• Temazepam
• Tipranavir
• Triazolam
• Voriconazole

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is not recommended. Your doctor may decide not to treat you with this medication, change some of the other medicines you take, or give you special instructions about the use of food, alcohol, or tobacco.

• Tobacco

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Caffeine

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Abnormal changes in menstrual or uterine bleeding
• Blood clots (or history of) or
• Gallbladder disease or gallstones (or history of) or
• Heart or circulation problems or
• High blood cholesterol or
• High blood pressure (hypertension) or
• Liver disease (or history of) or
• Mental problems—Combination contraceptives may make these conditions worse or, rarely, cause them to occur again.
• Cancer, including breast cancer— Contraceptives may worsen some cancers, especially when breast, cervical, or uterine cancers already exist. Use of monthly injectable contraceptives is not recommended if you have any of these conditions. If you have a family history of breast disease, injectable contraceptives may still be a good choice but you may need to be tested more often

• Diabetes mellitus (sugar diabetes)—Use of combination contraceptives may cause an increase, usually only a small increase, in your blood sugar and usually does not affect the amount of diabetes medicine that you take.
• Migraine headaches—Combination contraceptives may cause fluid build-up and may cause these conditions to become worse; however, some people have fewer migraine headaches when they use contraceptives

More common

• Bloating or swelling of face, hands, lower legs and/or feet
• cough
• difficulty swallowing
• dizziness
• fast heartbeat
• hives
• itching
• loss of appetite and nausea
• puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
• rapid weight gain
• shortness of breath
• tightness in chest
• unusual tiredness or weakness
• vomiting blood
• wheezing
• yellow eyes or skin

Symptoms of overdose—More common

• Nausea
• menstrual irregularities
• vaginal bleeding
• vomiting

More common

• Abdominal pain or enlarged abdomen
• absent or missed menstrual periods
• acne
• allergic rash
• brown, blotchy spots on skin
• decreased sex drive
• depression
• hair loss/thinning of hair
• headache
• increased amount of menstrual bleeding, or normal bleeding that comes earlier
• lack or loss of strength