Conjugated estrogens (intravenous route)

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies have not been performed on the relationship of age to the effects of Premarin® injection in the pediatric population. Safety and efficacy have not been established.

Although appropriate studies on the relationship of age to the effects of Premarin® injection have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have breast cancer, stroke, or dementia, which may require caution in patients receiving this medicine.

Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amifampridine
• Bupropion
• Cosyntropin
• Donepezil

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Etoricoxib
• Ginseng
• Levothyroxine
• Licorice
• Tipranavir

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Blood clots (e.g., deep vein thrombosis, pulmonary embolism), active or history of or
• Breast cancer, known or suspected, or a history of or
• Heart attack, history of or
• Liver disease or
• Protein C, protein S, or other known blood clotting disorders or
• Stroke, history of or
• Tumors (estrogen-dependent), known or suspected—Should not be used in patients with these conditions.

• Asthma or
• Cancer, history of or
• Diabetes or
• Edema (fluid retention or body swelling) or
• Endometriosis or
• Epilepsy (seizures) or
• Gallbladder disease or
• Heart disease or
• Hereditary angioedema (swelling of the face, lips, tongue, or throat) or
• Hypercalcemia (high calcium in the blood) or
• Hypertension (high blood pressure) or
• Hypertriglyceridemia (high triglycerides or fats in the blood) or
• Hypocalcemia (low calcium in the blood) or
• Hypothyroidism (an underactive thyroid) or
• Jaundice during pregnancy or from using hormonal therapy in the past or
• Liver tumors or
• Migraine headache or
• Porphyria (an enzyme problem) or
• Systemic lupus erythematosus (SLE)—Use with caution. May make these conditions worse.

Incidence not known

• Abdominal or stomach cramps, pain, or tenderness
• anxiety
• backache
• blistering, peeling, or loosening of the skin
• bloody or clay-colored stools
• changes in skin color
• chest pain or discomfort
• chills or fever
• clear or bloody discharge from the nipple
• cough or sore throat
• darkened urine
• difficulty with speaking
• dizziness, lightheadedness, or confusion
• double vision
• fainting
• fast heartbeat
• fluid-filled skin blisters
• headache, severe and throbbing
• heartburn or indigestion
• heavy bleeding
• inability to move the arms, legs, or facial muscles
• irregular heartbeats
• joint or muscle pain
• loss of appetite
• loss of bladder control
• lump in the breast or under the arm
• muscle cramps in the hands, arms, feet, legs, or face
• muscle spasm or jerking of all extremities
• nausea, vomiting, or diarrhea
• numbness and tingling around the mouth, fingertips, or feet
• pain or discomfort in the arms, jaw, back, or neck
• pain, redness, or swelling in the arm or leg
• painful or tender cysts in the breasts
• painful, red lumps under the skin, mostly on the legs
• rash, hives or welts
• rectal bleeding
• red, irritated eyes
• redness or swelling of the breast
• sensitivity to the sun
• sore on the skin of the breast that does not heal
• sores, ulcers, or white spots in the mouth or on the lips
• stomach discomfort or upset
• sudden loss of consciousness
• sudden shortness of breath or troubled breathing
• sweating
• swelling of the foot or leg
• tremor
• unusual tiredness or weakness
• vomiting of blood
• yellow eyes or skin

Incidence not known

• Brown, blotchy spots on exposed skin
• decreased interest in sexual intercourse
• difficulty of wearing contact lenses
• hair loss in the scalp
• increase or decrease in weight
• increased hair growth, especially on the face
• mental depression
• muscle pain or stiffness
• pain or swelling at the injection site
• twitching, uncontrolled movements of the tongue, lips, face, arms, or legs