Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

  1. Alka-Seltzer Plus Cold and Sinus
  2. Genapap Sinus
  3. Infants Tylenol Plus Cold
  4. Mapap Sinus PE
  5. Sinutab Sinus
  6. Sudafed PE Sinus Headache

Canadian Brand Name

  1. Allergy Sinus Medication Extra Strength
  2. Childrens Tylenol Cold Bubble Gum Flavor
  3. Childrens Tylenol Cold Cherry Flavor
  4. Childrens Tylenol Cold Fruit Flavor
  5. Colds And Flu With Vitamin C Extra Strength
  6. Colds And Flu With Vitamin C Regular Strength
  7. Counteract Childrens Cold Multi-Symptom Plus Cough
  8. Dimetapp Extra Strength Nighttime Cold
  9. Dimetapp Nighttime Cold
  10. Dristan Extra Strength
  11. Extra Strength Tylenol Allergy Sinus Multi-Symptom Relief
  12. Extra Strength Tylenol Sinus with Coolburst - Nighttime


In November 2000, the Food and Drug Administration (FDA) issued a public health warning regarding phenylpropanolamine (PPA) due to the risk of hemorrhagic stroke. The FDA, supported by results of a research program, requested that manufacturers voluntarily discontinue marketing products that contain PPA and that consumers work with their healthcare providers to select alternative products.

Antihistamine, decongestant, and analgesic combinations are taken by mouth to relieve the sneezing, runny nose, sinus and nasal congestion (stuffy nose), fever, headache, and aches and pain of colds, influenza, and hay fever. These combinations do not contain any ingredient to relieve coughs.

Antihistamines are used to relieve or prevent the symptoms of hay fever and other types of allergy. They may also help relieve some symptoms of the common cold, such as sneezing and runny nose. They work by preventing the effects of a substance called histamine, which is produced by the body. Antihistamines contained in these combinations are:

brompheniramine, chlorpheniramine, dexbrompheniramine, diphenhydramine, pheniramine, phenyltoloxamine, pyrilamine, and triprolidine.

Decongestants, such as phenylephrine, and pseudoephedrine, produce a narrowing of blood vessels. This leads to clearing of nasal congestion, but it may also cause an increase in blood pressure in patients who have high blood pressure.

Analgesics, such as acetaminophen and salicylates (e.g., aspirin, sodium salicylate), are used in these combination medicines to help relieve fever, headache, aches, and pain.

Some of these medicines are available without a prescription. However, your doctor may have special instructions on the proper dose of these medicines for your medical condition.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .

This product is available in the following dosage forms:

  • Packet
  • Solution
  • Tablet, Effervescent
  • Powder for Solution
  • Tablet
  • Capsule, Liquid Filled

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