Safety and side effects
When used as a supplement in appropriate doses, vitamin B-6 is likely safe. High intake of vitamin B-6 through food hasn't been shown to be harmful.
However, too much vitamin B-6 also can cause:
- A lack of muscle control or coordination of voluntary movements (ataxia)
- Painful, disfiguring skin lesions
- Gastrointestinal symptoms, such as heartburn and nausea
- Sensitivity to sunlight (photosensitivity)
- Reduced ability to sense pain or extreme temperatures
Check with your doctor before taking vitamin B-6 if you are taking medications. Possible drug interactions include:
Oct. 17, 2017
- Altretamine (Hexalen). Taking vitamin B-6 with this chemotherapy drug might reduce its effectiveness, especially when also combined with the chemotherapy drug cisplatin.
- Barbiturates. Taking vitamin B-6 with a drug that acts as a central nervous system depressant (barbiturate) might decrease the drug's duration and intensity.
- Anticonvulsants. Taking vitamin B-6 with fosphenytoin (Cerebyx) or phenytoin (Dilantin, Phenytek) might decrease the drug's duration and intensity.
- Levodopa. Avoid taking vitamin B-6 with this drug used to treat Parkinson's disease. Vitamin B-6 might reduce the effectiveness of the drug.
- Vitamin B6 dietary supplement fact sheet. National Institutes of Health Office of Dietary Supplements. https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional. Accessed Aug. 23, 2017.
- Pyridoxine. Micromedex 2.0 Healthcare Series. http://www.micromedexsolutions.com. Accessed Aug. 23, 2017.
- Pyridoxine hydrochloride (B6) oral. Facts & Comparisons eAnswers. http://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed Aug. 23, 2017.