Tetralogy of Fallot is a combination of four heart changes present at birth. There is a hole in the heart called a ventricular septal defect. There also is a narrowing of the pulmonary valve or other area along the pathway between the heart and lungs. Narrowing of the pulmonary valve is called pulmonary stenosis. The body's main artery, called the aorta, is misplaced. The lower right heart chamber wall is thickened, a condition called right ventricular hypertrophy. Tetralogy of Fallot changes how blood flows through the heart and to the rest of the body.
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