Your doctor may diagnose systemic mastocytosis through blood or urine tests or imaging tests like X-rays, ultrasounds, and CT scans. You may need a test to collect a sample of bone marrow to study in a lab. These tests look for high levels of mast cells or the substances they release.


Treatment for systemic mastocytosis may include medications like antihistamines, aspirin, and drugs that work against the substances released by mast cells in your body. If you have a severe allergic reaction, you may need an injection of epinephrine. Aggressive forms of systemic mastocytosis may need powerful chemotherapy drugs to destroy mast cells.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this disease.

Systemic mastocytosis care at Mayo Clinic

Dec. 21, 2018
  1. Pardanani A. Systemic mastocytosis in adults: 2017 update on diagnosis, risk stratification and management. American Journal of Hematology. 2016;91:1146.
  2. Mastocytosis. Genetic and Rare Disease Information Center. https://rarediseases.info.nih.gov/diseases/6987/mastocytosis. Accessed Feb. 20, 2017.
  3. Castells MC. Mastocytosis (cutaneous and systemic): Epidemiology, pathogenesis, and clinical manifestations. http://www.uptodate.com/home. Accessed Feb. 19, 2017.
  4. AskMayoExpert. Systemic mastocytosis. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2016.
  5. Brown AY. Allscripts EPSi. Mayo Clinic, Rochester, Minn. Jan. 25, 2017.
  6. Akin C, et al. Systemic mastocytosis: Management and prognosis. http://www.uptodate.com/home. Accessed Feb. 19, 2017.
  7. Pardanani A. Systemic mastocytosis: Evolving lessons from large patient registry datasets. American Journal of Hematology. 2016;91:654.


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