If an outbreak of smallpox were to occur today, it's likely that most doctors wouldn't realize what it was in its early stages, which would allow the disease to spread.
Even one confirmed case of smallpox would be considered an international health emergency. The Centers for Disease Control and Prevention can do definitive testing using a tissue sample taken from one of the lesions on the skin of the infected person.
No cure for smallpox exists. In the event of an infection, treatment would focus on relieving symptoms and keeping the person from becoming dehydrated. Antibiotics might be prescribed if the person also develops a bacterial infection in the lungs or on the skin.
Tecovirimat (Tpoxx), an antiviral drug, was approved for use in the U.S. in 2018. However, it wasn't tested in people who are sick with smallpox, so it's not known if it is an effective drug option. A trial tested its safety in humans and found it to be as safe as the placebo. Other antiviral drugs continue to be studied.
Sept. 22, 2020
- Friedman HM, et al. The epidemiology, pathogenesis and clinical manifestations of smallpox. https://www.uptodate.com/home. Accessed Feb. 22, 2017.
- Smallpox vaccine: Drug information. https://www.uptodate.com/home. Accessed Feb. 22, 2017.
- Smallpox vaccine: Patient drug information. https://www.uptodate.com/home. Accessed Feb. 22, 2017.
- Hall JB, et al., eds. Biological warfare. In: Principles of Critical Care. 4th ed. New York, N.Y.: McGraw-Hill Education; 2015. http://accessmedicine.mhmedical.com. Accessed Feb. 22, 2017.
- Smallpox. Centers for Disease Control and Prevention. https://www.cdc.gov/smallpox/. Accessed Feb. 22, 2017.
- Frequently asked questions and answers on smallpox. World Health Organization. http://www.who.int/csr/disease/smallpox/faq/en/#. Accessed Feb. 22, 2017.
- Friedman HM, et al. Variola virus (smallpox). https://www.uptodate.com/contents/search. Accessed Aug. 28, 2020.
- Isaacs SN, et al. Vaccinia virus as the smallpox vaccine. https://www.uptodate.com/contents/search. Accessed Sept. 2, 2020.
- Tosh PK (expert opinion). Mayo Clinic. Sept. 2, 2020.
- Vaccines. Centers for Disease Control and Prevention. https://www.cdc.gov/smallpox/clinicians/vaccines.html. Accessed Sept. 2, 2020.
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