Print Departments and specialties Mayo Clinic has one of the largest and most experienced practices in the United States, with campuses in Arizona, Florida and Minnesota. Staff skilled in dozens of specialties work together to ensure quality care and successful recovery. Departments that treat this condition Breast and Melanoma Surgical Oncology in Rochester Breast Cancer Surgery Program in Jacksonville Breast Clinic Cancer Care at Mayo Clinic Laboratory Medicine and Pathology Oncology (Medical) Radiation Oncology Radiology Surgical Oncology and Endocrine Surgery in Arizona Areas that research this condition Radiology Research ResearchMayo Clinic doctors and scientists are studying ways to improve the prevention, diagnosis and treatment of recurrent breast cancer. Mayo Clinic Comprehensive Cancer Center is one of a select group of facilities that received a Specialized Program of Research Excellence (SPORE) grant for breast cancer research from the U.S. National Cancer Institute. Mayo Clinic doctors and researchers are studying emerging technologies and therapies for recurrent breast cancer, including: CAR-T cell therapy, which reprograms the body's immune cells to help find and attack cancer cells. Therapeutic breast cancer vaccines designed to help the immune system recognize and respond to breast cancer cells. Radiotheranostics, which combines advanced imaging with targeted radiation treatments that use radiopharmaceuticals to deliver radiation more precisely to cancer cells. Molecular profiling and biomarker testing to better understand the cancer and help guide personalized treatment decisions. Blood-based testing, including circulating tumor DNA (ctDNA) testing, to help monitor cancer activity and guide treatment planning over time. New targeted therapies for hormone receptor positive, HER2-positive, HER2-low and triple-negative breast cancers. Oral targeted medicines designed to treat cancers with specific genetic changes or resistance to prior treatments. Immunotherapy approaches that help the immune system identify and attack cancer cells. Combination treatment approaches that pair standard therapies with newer targeted or immune-based treatments. Advanced imaging approaches, including specialized PET imaging, to help identify where recurrent cancer is active and guide treatment decisions. Clinical trials for recurrent, metastatic and treatment-resistant breast cancer that may provide access to emerging therapies and new treatment approaches. PublicationsSee a list of publications about recurrent breast cancer by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine. Research Profiles Edit search filters close Narrow your search By location Arizona Florida Minnesota View all View all physicians • All Locations Ames, Matthew M. Ph.D. Minnesota Ballman, Karla V. Ph.D. Minnesota Goetz, Matthew P. M.D. Minnesota Hawse, John R. IV Ph.D. Minnesota Knutson, Keith L. Ph.D. Florida Leon-Ferre, Roberto A. M.D. Minnesota Mutter, Robert W. M.D. Minnesota Nassar, Aziza M.D., M.P.H. Florida Vachon, Celine M. Ph.D. Minnesota Vallow, Laura A. M.D. Florida Yadav, Siddhartha M.B.B.S., M.D. Minnesota By Mayo Clinic Staff Recurrent breast cancer care at Mayo Clinic Request an appointment Diagnosis & treatmentCare at Mayo Clinic July 21, 2026 Print Living with recurrent breast cancer? Connect with others like you for support and answers to your questions in the Breast Cancer support group on Mayo Clinic Connect, a patient community. Breast Cancer Discussions Triple negative invasive lobular breast cancer 19 Replies Mon, Jul 27, 2026 chevron-right My body's immune system after cancer 22 Replies Sun, Jul 26, 2026 chevron-right Aromatase Inhibitors: Did you decide to go on them or not? 1260 Replies Sat, Jul 25, 2026 chevron-right See more discussions Related Associated Procedures Bone scan Breast biopsy Breast cancer supportive therapy and survivorship Breast cancer surgery Breast MRI Chemotherapy Chemotherapy for breast cancer Chest X-rays CT scan Hormone therapy for breast cancer Mammogram Mastectomy MRI Positron emission tomography (PET) scan Radiation therapy Radiation therapy for breast cancer Ultrasound X-ray Show more associated procedures Products & Services A Book: Beyond Breast Cancer A Book: Mayo Clinic Family Health Book LISTEN: What to do when you've been diagnosed with breast cancer Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Recurrent breast cancerSymptoms&causesDiagnosis&treatmentDoctors&departmentsCare atMayoClinic Research: It's all about patients Show transcript for video Research: It's all about patients [MUSIC PLAYING] Joseph Sirven, M.D., Professor of Neurology, Mayo Clinic: Mayo's mission is about the patient. The patient comes first. So the mission and research here is to advance how we can best help the patient, how to make sure the patient comes first in care. So in many ways, it's a cycle. It can start with as simple as an idea worked on in a laboratory, brought to the patient bedside, and if everything goes right — and let's say it's helpful or beneficial — then brought on as a standard approach. And I think that is one of the unique characteristics of Mayo's approach to research — that patient-centeredness — that really helps to put it in its own spotlight. CON-20377118 Diseases & Conditions Recurrent breast cancer