Diagnosis

Your health care provider will examine your nails and perhaps take some nail clippings or scrape debris from under your nail. These samples are sent to a lab to identify the cause of your symptoms.

Other conditions, such as psoriasis, can mimic a fungal infection of the nail. Microorganisms such as yeast and bacteria also can infect nails. Knowing the cause of your infection helps determine the best treatment.

Treatment

Treatment for toenail fungus isn't always needed. And sometimes self-care and nonprescription products clear up the infection. Talk with your health care provider if your condition doesn't improve. Treatment depends on the severity of your condition and the type of fungus causing it. It can take months to see results. And even if your nail condition improves, repeat infections are common.

Medications

Your health care provider may prescribe antifungal drugs that you take by mouth (orally) or apply to the nail.

  • Oral antifungal drugs. These drugs are often the first choice. One option is itraconazole (Sporanox). These drugs help a new nail grow free of infection, slowly replacing the infected part.

    You typically take this type of drug daily for 6 to 12 weeks. But you won't see the end result of treatment until the nail grows back completely. It may take four months or longer to eliminate an infection. Treatment success rates with these drugs appear to be lower in adults over age 65.

    Oral antifungal drugs may cause side effects such as rash and liver damage. Or they may interfere with other prescription drugs. You may need occasional blood tests to check on how you're doing with these types of drugs. Health care providers may not recommend oral antifungal drugs for people with liver disease or congestive heart failure or those taking certain medications.

  • Medicated nail polish. Your health care provider may prescribe an antifungal nail polish called ciclopirox (Penlac). You paint it on your infected nails and surrounding skin once a day. After seven days, you wipe the piled-on layers clean with alcohol and begin fresh applications. You may need to use this type of nail polish daily for almost a year.
  • Medicated nail cream. Your health care provider may prescribe an antifungal cream, such as efinaconazole (Jublia) and tavaborole (Kerydin). You rub this product into your infected nails after soaking. These creams may work better if you first thin the nails. This helps the medication get through the hard nail surface to the underlying fungus.

    To thin nails, you apply a nonprescription lotion containing urea. Or your health care provider may thin the surface of the nail (debride) with a file or other tool.

    Antifungal nail creams may cause side effects such as rash.

Surgery

Your health care provider might suggest temporary removal of the nail so that the antifungal drug can be applied directly to the infection under the nail.

The most effective but least used option is surgery to permanently remove the nail and its root.

From Mayo Clinic to your inbox

Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Click here for an email preview.

To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. If you are a Mayo Clinic patient, this could include protected health information. If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail.

Lifestyle and home remedies

Often, you can take care of a fungal nail infection at home:

  • Try nonprescription antifungal nail creams and ointments. Several products are available, such as terbinafine (Lamisil). If you notice white markings on the surfaces of the nails, file them off, soak your nails in water, dry them, and apply the medicated cream or lotion. Even if this clears up your symptoms, it's common for the infection to come back.
  • Trim and thin the nails. This helps reduce pain by reducing pressure on the nails. Also, if you do this before applying an antifungal, the drug can reach deeper layers of the nail.

Before trimming or using a nail file to thin thick nails, soften them with urea-containing creams. See a health care provider for foot care if you have a condition that causes poor blood flow to your feet.

Alternative medicine

Some research suggests that the nutritional supplement biotin might help strengthen weak or brittle fingernails. Talk with your health care provider if you have any questions or concerns about whether this is right for you.

Also, some research shows that tea tree oil has anti-fungal effects. It is often used to treat nail fungus.

Preparing for your appointment

You're likely to start by seeing your primary care provider. In some cases when you call to set up an appointment, you may be referred immediately to either a doctor who specializes in skin conditions (dermatologist) or one who specializes in foot conditions (podiatrist).

Here are some steps you can take to prepare for your appointment:

  • List your symptoms, including any that may seem unrelated to nail fungus.
  • List key personal information, including any major stresses or recent life changes.
  • List all the medications, vitamins and supplements you're taking.
  • List questions to ask your health care provider.

For nail fungus, your questions might include:

  • What is likely causing my symptoms or condition?
  • What are other possible causes for my symptoms or condition?
  • What tests do I need?
  • What is the best course of action?
  • What are the alternatives to the primary approach you're suggesting?
  • I have other health conditions. How can I best manage them together?
  • Is a generic alternative available for the medicine you're prescribing?
  • Do you have any brochures or other printed material that I can take home? Do you recommend any websites on nail fungus?
May 15, 2024
  1. AskMayoExpert. Fungal nail infection (onychomycosis). Mayo Clinic; 2022.
  2. Kelly AP, et al., eds. Nail disorders. In: Taylor and Kelly's Dermatology for Skin of Color. 2nd ed. McGraw Hill; 2016. https://accessmedicine.mhmedical.com. Accessed May 3, 2022.
  3. Onychomycosis. Merck Manual Professional Version. https://www.merckmanuals.com/professional/dermatologic-disorders/nail-disorders/onychomycosis. Accessed May 3, 2022.
  4. Toenail fungus. American Podiatric Medical Association. https://www.apma.org/Patients/FootHealth.cfm?ItemNumber=1523. Accessed May 3, 2022.
  5. Foley K, et al. Topical and device-based treatments for fungal infections of the toenails. Cochrane Database of Systematic Reviews. 2020; doi:10.1002/14651858.CD012093.pub2.
  6. Lipner SR, et al. Onychomycosis: Clinical overview and diagnosis. Journal of the American Academy of Dermatology. 2019; doi:org/10.1016/j.jaad.2018.03.062.
  7. Ameen M, et al. British Association of Dermatologists' guidelines for the management of onychomycosis 2014. British Journal of Dermatology. 2014; doi:10.1111/bjd.13358.
  8. Taylor Frazier W. Onychomycosis: Rapid evidence review. American Family Physician. 2021;104:359.
  9. Gibson LE (expert opinion). Mayo Clinic. May 25, 2022.
  10. Biotin. Natural medicines. https://naturalmedicines.therapeuticreseardch.com. Accessed May 3, 2022.
  11. Tea tree oil. Natural medicines. https://naturalmedicines.therapeuticreseardch.com. Accessed May 3, 2022.