Diagnosis

To diagnose malaria, your doctor will likely review your medical history and recent travel, conduct a physical exam, and order blood tests. Blood tests can indicate:

  • The presence of the parasite in the blood, to confirm that you have malaria
  • Which type of malaria parasite is causing your symptoms
  • If your infection is caused by a parasite resistant to certain drugs
  • Whether the disease is causing any serious complications

Some blood tests can take several days to complete, while others can produce results in less than 15 minutes. Depending on your symptoms, your doctor may order additional diagnostic tests to assess possible complications.

Treatment

Malaria is treated with prescription drugs to kill the parasite. The types of drugs and the length of treatment will vary, depending on:

  • Which type of malaria parasite you have
  • The severity of your symptoms
  • Your age
  • Whether you're pregnant

Medications

The most common antimalarial drugs include:

  • Chloroquine phosphate. Chloroquine is the preferred treatment for any parasite that is sensitive to the drug. But in many parts of the world, parasites are resistant to chloroquine, and the drug is no longer an effective treatment.
  • Artemisinin-based combination therapies (ACTs). ACT is a combination of two or more drugs that work against the malaria parasite in different ways. This is usually the preferred treatment for chloroquine-resistant malaria. Examples include artemether-lumefantrine (Coartem) and artesunate-mefloquine.

Other common antimalarial drugs include:

  • Atovaquone-proguanil (Malarone)
  • Quinine sulfate (Qualaquin) with doxycycline (Oracea, Vibramycin, others)
  • Primaquine phosphate

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Preparing for your appointment

If you suspect you have malaria or that you've been exposed, you're likely to start by seeing your family doctor. However, in some cases when you call to set up an appointment, you may be referred to an infectious disease specialist. If you have severe symptoms — especially during or after travel in an area where malaria is common — seek emergency medical attention.

What you can do

Before your appointment, you might want to write down answers to the following questions:

  • What are your symptoms, and when did they start?
  • Where have you traveled recently?
  • How long did you travel and when did you return?
  • Did you take any preventive drugs related to your travel?
  • What other medications do you take, including dietary supplements and herbal remedies?
Feb. 03, 2021
  1. AskMayoExpert. Malaria. Mayo Clinic; 2019.
  2. Jameson JL, et al., eds. Malaria. In: Harrison's Principles of Internal Medicine. 20th ed. New York, N.Y.: The McGraw-Hill Companies; 2018. https://accessmedicine.mhmedical.com. Accessed Oct. 9, 2018.
  3. Bennett JE, et al. Malaria (plasmodium species). In: Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Dec. 15, 2020.
  4. Malaria. Merck Manual Professional Version. http://www.merckmanuals.com/professional/infectious-diseases/extraintestinal-protozoa/malaria. Accessed Dec. 15, 2020.
  5. Brunette GW, et al., eds. CDC Yellow Book 2020: Health Information for International Travel. Oxford University Press; 2019. https://wwwnc.cdc.gov/travel/page/yellowbook-home. Accessed Dec. 15, 2020.
  6. Breman JG. Clinical manifestations of malaria in nonpregnant adults and children. https://www.uptodate.com/contents/search. Accessed Dec. 15, 2020.
  7. Daily J. Treatment of uncomplicated falciparum malaria in nonpregnant adults and children. https://www.uptodate.com/contents/search. Accessed Dec. 15, 2020.
  8. World malaria report 2020. World Health Organization. https://www.who.int/publications/i/item/9789240015791. Accessed Dec. 15, 2020.
  9. Sanchez L, et al. Antibody responses to the RTS,S/AS01E vaccine and Plasmodium falciparum antigens after a booster dose within the phase 3 trial in Mozambique. NPJ Vaccines. 2020; doi:10.1038/s41541-020-0192-7.

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