Lupus nephritis is a type of kidney inflammation. It's a common complication in people who have systemic lupus erythematosus — more commonly known as lupus.

Lupus is an autoimmune disease in which your immune system produces proteins called autoantibodies that attack your own tissues and organs.

Lupus nephritis occurs when lupus autoantibodies affect structures in your kidneys that filter out waste. This causes kidney inflammation and may lead to blood in the urine (hematuria), protein in the urine (proteinuria), high blood pressure, impaired kidney function or even kidney failure.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this disease.

Lupus nephritis care at Mayo Clinic

Aug. 23, 2017
  1. Lupus nephritis. National Institute of Diabetes and Digestive and Kidney Diseases. http://www.niddk.nih.gov/health-information/health-topics/kidney-disease/lupus-nephritis/Pages/index.aspx. Accessed June 14, 2016.
  2. Longo DL, et al., eds. Glomular diseases. In: Harrison's Principles of Internal Medicine. 19th ed. New York, N.Y.: McGraw-Hill Education; 2015. http://accessmedicine.com. Accessed June 14, 2016.
  3. Bomback AS, et al. Diagnosis and classification of renal disease in systemic lupus erythematosus. http://www.uptodate.com/home. Accessed June 14, 2016.
  4. Dialysis. National Kidney Foundation. https://www.kidney.org/atoz/content/dialysisinfo. Accessed June 16, 2016.
  5. Fervenza FC (expert opinion). Mayo Clinic, Rochester, Minn. July 7, 2016.