Print Departments and specialties Mayo Clinic has one of the largest and most experienced practices in the United States, with campuses in Arizona, Florida and Minnesota. Staff skilled in dozens of specialties work together to ensure quality care and successful recovery. Departments that treat this condition Cancer Care at Mayo Clinic Clinical Genomics Early-Onset and Hereditary GI Cancers Program Early-Onset Colorectal Cancer Group Familial Cancer Program Hereditary Cancer Clinic Oncology (Medical) Pediatric Hematology/Oncology ResearchMayo Clinic researchers are studying Li-Fraumeni syndrome and other inherited cancer conditions to improve genetic testing, cancer detection and prevention. Recent Mayo Clinic research has examined mosaic Li-Fraumeni syndrome. This includes how testing different tissues may help show if a TP53 gene change is present in many parts of the body or is limited to blood cells. Mayo Clinic researchers also study rare genetic conditions through Clinical Genomics and collect donated samples and health information in biobanks to better understand how genes affect health and cancer risk. Researchers also are studying how cancers may begin in people with inherited cancer risk. For example, Mayo Clinic researchers used cells donated by a patient with another inherited cancer condition, as well as Li-Fraumeni syndrome, to look for very early changes in fallopian tube cells that might lead to ovarian cancer. A Mayo Clinic living fallopian tube biobank includes samples from people with inherited cancer-related gene changes and is being used to study earlier cancer detection and ways to lower cancer risk. PublicationsSee a list of publications about Li-Fraumeni syndrome by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine. Research Profiles Edit search filters close Narrow your search By location Arizona Florida Minnesota View all View all physicians • Florida By Mayo Clinic Staff Request an appointment Survival rates Aug. 28, 2026 Print Li-Fraumeni syndromeSymptoms&causesDiagnosis&treatmentSurvivalratesDoctors&departments Research: It's all about patients Show transcript for video Research: It's all about patients [MUSIC PLAYING] Joseph Sirven, M.D., Professor of Neurology, Mayo Clinic: Mayo's mission is about the patient. The patient comes first. So the mission and research here is to advance how we can best help the patient, how to make sure the patient comes first in care. So in many ways, it's a cycle. It can start with as simple as an idea worked on in a laboratory, brought to the patient bedside, and if everything goes right — and let's say it's helpful or beneficial — then brought on as a standard approach. And I think that is one of the unique characteristics of Mayo's approach to research — that patient-centeredness — that really helps to put it in its own spotlight. CON-20604858 Diseases & Conditions Li-Fraumeni syndrome