Print ResearchAs a major heart failure research center, Mayo Clinic focuses on the diagnosis of heart failure in its earliest stages. Mayo Clinic researchers study treatments for people with heart failure. You may have the opportunity to participate in clinical trials of experimental therapies. Learn more about research in the Cardiovascular Research Center. Publications See a list of publications about heart failure with reduced ejection fraction (HFrEF) by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine. By Mayo Clinic Staff Request an appointment Stages Sept. 26, 2026 Print Related Associated Procedures Cardiac catheterization Cardiac rehabilitation Cardiac resynchronization therapy Chest X-rays Coronary angiogram Coronary artery bypass graft CT scan Echocardiogram Electrocardiogram (ECG or EKG) Heart transplant Implantable cardioverter-defibrillators (ICDs) Liver function tests MRI Palliative care Stress test Ventricular assist device Show more associated procedures Heart failure with reduced ejection fraction (HFrEF)Symptoms&causesDiagnosis&treatmentStagesDoctors&departments Research: It's all about patients Show transcript for video Research: It's all about patients [MUSIC PLAYING] Joseph Sirven, M.D., Professor of Neurology, Mayo Clinic: Mayo's mission is about the patient. The patient comes first. So the mission and research here is to advance how we can best help the patient, how to make sure the patient comes first in care. So in many ways, it's a cycle. It can start with as simple as an idea worked on in a laboratory, brought to the patient bedside, and if everything goes right — and let's say it's helpful or beneficial — then brought on as a standard approach. And I think that is one of the unique characteristics of Mayo's approach to research — that patient-centeredness — that really helps to put it in its own spotlight. CON-20607359 Diseases & Conditions Heart failure with reduced ejection fraction (HFrEF)