Functional dyspepsia (dis-PEP-see-uh) is a term for recurring signs and symptoms of indigestion that have no obvious cause. Functional dyspepsia is also called nonulcer stomach pain or nonulcer dyspepsia.

Functional dyspepsia is common and can be long lasting — although signs and symptoms are mostly intermittent. These signs and symptoms resemble those of an ulcer, such as pain or discomfort in your upper abdomen, often accompanied by bloating, belching and nausea.


Signs and symptoms of functional dyspepsia may include:

  • Pain or burning in the stomach, bloating, excessive belching, or nausea after meals
  • An early feeling of fullness (satiety) when eating
  • Pain in the stomach that may sometimes occur unrelated to meals or may be relieved with meals

When to see a doctor

Make an appointment with your doctor if you experience persistent signs and symptoms that worry you.

Seek immediate medical attention if you experience:

  • Bloody vomit
  • Dark, tarry stools
  • Shortness of breath
  • Pain that radiates to your jaw, neck or arm
  • Unexplained weight loss


It's not clear what causes functional dyspepsia. Doctors consider it a functional disorder, which means that routine testing may not show any abnormalities. Hence, it is diagnosed based on symptoms.

Risk factors

Factors that can increase the risk of functional dyspepsia include:

  • Female sex
  • Use of certain over-the-counter pain relievers, such as aspirin and ibuprofen (Advil, Motrin IB, others), which can cause stomach problems
  • Smoking
  • Anxiety or depression
  • History of childhood physical or sexual abuse
  • Helicobacter pylori infection

Functional dyspepsia care at Mayo Clinic

Jan. 29, 2021
  1. Ford AC, et al. Functional dyspepsia. The Lancet. 2020; doi:10.1016/S0140-6736(20)30469-4.
  2. Feldman M, et al., eds. Dyspepsia. In: Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 11th ed. Elsevier; 2021. https://www.clinicalkey.com. Accessed Nov. 16, 2020.
  3. Longstreth GF, et al. Functional dyspepsia in adults. https://www.uptodate.com/contents/search. Accessed Nov. 16, 2020.
  4. Indigestion (dyspepsia). National Institute for Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/digestive-diseases/indigestion-dyspepsia/all-content. Accessed Nov. 16, 2020.
  5. Goldman L, et al., eds. Functional gastrointestinal disorders: Irritable bowel syndrome, dyspepsia, esophageal chest pain, and heartburn. In: Goldman-Cecil Medicine. 26th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Nov. 16, 2020.
  6. Mounsey A, et al. Functional dyspepsia: Diagnosis and management. American Family Physician. 2020; doi:10.1097/MOG.0b013e328358ad9b.
  7. Li J, et al. A combination of peppermint oil and caraway oil for the treatment of functional dyspepsia: A systematic review and meta-analysis. Evidence-Based Complementary and Alternative Medicine. 2019; doi:10.1155/2019/7654947.
  8. Masuy I, et al. Review article: Treatment options for functional dyspepsia. Alimentary Pharmacology & Therapeutics. 2019; doi:10.1111/apt.15191.
  9. Brown AY. Allscripts EPSi. Mayo Clinic. Nov. 6, 2020.
  10. Kashyap PC (expert opinion). Mayo Clinic. Jan. 4, 2021.


Associated Procedures