Stages By Mayo Clinic Staff If you're diagnosed with cutaneous T-cell lymphoma (CTCL), the next step is to find out how much and where the cancer has spread. This is called the stage. Healthcare professionals may use imaging and biopsies to determine the stage by looking at how big the cancer is, its location and the distance it traveled from where it first started. Your healthcare team creates your treatment plan based on the stage. Cutaneous T-cell lymphoma is not staged the same way for every type. The stages of CTCL often range from 1 to 4 and describe the extent the cancer affects the skin, lymph nodes and organs. For mycosis fungoides and Sezary syndrome, stages are also assigned to describe how the cancer involves the blood. A higher stage number means the cancer is more advanced. Skin. Lower stage numbers typically mean the cancer is limited to smaller amounts of the skin. As the stage numbers go up, the cancer can progress to larger areas of the skin or tumors on the skin. Higher stages also mean the cancer has traveled to other areas of the body. Lymph nodes. When the stage numbers go up, that means more lymph nodes may be involved. Higher stages also may mean that the lymph nodes are located deeper within the body. Organs. Higher stages usually mean the cancer traveled outside of the skin and lymph nodes to other organs. Request an appointment Diagnosis & treatmentDoctors & departments April 29, 2026 Share on: FacebookTwitter Living with cutaneous T-cell lymphoma? Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. Blood Cancers & Disorders Discussions Polycythemia Vera: Just been diagnosed 485 Replies Wed, May 27, 2026 chevron-right Mast Cell Activation Syndrome: What treatments help you? 31 Replies Tue, May 26, 2026 chevron-right My Bone Marrow Transplant (BMT/SCT) story: Will you share yours? 874 Replies Tue, May 26, 2026 chevron-right See more discussions Show references DeVita VT Jr, et al., eds. Cutaneous lymphomas. In: DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology. 12th ed. Wolters Kluwer; 2023. Accessed Jan. 30, 2026. Primary cutaneous lymphomas. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelinesdetail?category=1&id=1491. Accessed Oct. 7, 2024. AskMayoExpert. Mycosis fungoides and Sezary syndrome (adult). Mayo Clinic; 2024. Cutaneous T-cell lymphoma in adult. VisualDx. https://www.visualdx.com. Accessed Nov. 7, 2024. Cutaneous T-cell lymphoma. American Academy of Dermatology. https://www.aad.org/public/diseases/a-z/ctcl-overview. Accessed Nov. 11, 2024. Cutaneous T-cell lymphoma. Leukemia & Lymphoma Society. https://www.lls.org/publications?field_booklets_language_target_id_1=351&field_booklets_category_target_id=344&sort_by=title&view-type=card. Accessed Nov. 11, 2024. Niederhuber JE, et al., eds. Cutaneous T-cell lymphoma and cutaneous B-cell lymphoma. In: Abeloff's Clinical Oncology. 6th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Jan. 30, 2026. Lavin L, et al. Cutaneous T cell lymphoma following dupilumab therapy in patients with atopic dermatitis: Clinical review and recommendations. American Journal of Clinical Dermatology. 2025; doi:10.1007/s40257-025-00955-7. Mycosis fungoides and other cutaneous T-cell lymphomas treatment (PDQ) — Health professional version. National Cancer Institute. https://www.cancer.gov/types/lymphoma/hp/mycosis-fungoides-treatment-pdq. Accessed Jan. 30, 2026. Hoppe R, et al. Clinical manifestations, pathologic features, and diagnosis of mycosis fungoides. https://www.uptodate.com/contents/search. Accessed Jan. 30, 2026. Freedman S, et al. Clinical manifestations, pathologic features, and diagnosis of subcutaneous panniculitis-like T cell lymphoma. https://www.uptodate.com/contents/search. Accessed Jan. 30, 2026. Elsevier Point of Care. Clinical Overview: Cutaneous T-cell lymphomas (mycosis fungoides and Sézary syndrome). https://www.clinicalkey.com. Accessed Jan. 30, 2026. Willemze R. Primary cutaneous T cell lymphomas, rare subtypes. https://www.uptodate.com/contents/search. Accessed Jan. 30, 2026. Cutaneous lymphomas. National Comprehensive Cancer Care Network.https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1549. Accessed Jan. 30, 2026. Salama M, et al., eds. Indolent and aggressive mature T-cell and natural killer-cell lymphomas. In: Atlas of Diagnostic Hematology. Elsevier; 2026. https://www.clinicalkey.com. Accessed Jan. 30, 2026. American College of Surgeons. Primary cutaneous lymphomas. In: AJCC Cancer Staging System. American College of Surgeons; 2026. https://online.statref.com. Accessed Jan. 29, 2026. Related Associated Procedures Chemotherapy CT scan MRI Positron emission tomography (PET) scan Radiation therapy Skin biopsy Show more associated procedures Products & Services A Book: Mayo Clinic Family Health Book Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Cutaneous T-cell lymphomaSymptoms&causesDiagnosis&treatmentStagesDoctors&departmentsCare atMayoClinic CON-20155343 Diseases & Conditions Cutaneous T-cell lymphoma