Treatments and drugs

By Mayo Clinic Staff

There is no cure for cold urticaria, but treatment can help. Your doctor may recommend you try to prevent or reduce symptoms with home remedies, such as over-the-counter antihistamines. If self-care steps don't help, talk with your doctor about finding a prescription drug or combination of drugs that works best for you.

Prescription medications used to treat cold urticaria include:

  • Antihistamines. These medications block the symptom-producing release of histamine. Examples include fexofenadine (Allegra) and desloratadine (Clarinex).
  • Cyproheptadine. This medication is an antihistamine that also affects nerve impulses that lead to symptoms.
  • Doxepin (Silenor). Normally used to treat anxiety and depression, this medication can also reduce cold urticaria symptoms.
  • Omalizumab (Xolair). Normally used to treat asthma, this drug has been used successfully to treat a small number of people with cold urticaria who didn't respond to other medications.

If you have cold urticaria because of an underlying health problem, you may need medications or other treatment for that condition as well.

Nov. 21, 2014