Tests and procedures used in angiosarcoma diagnosis include:

  • Physical exam. Your doctor will thoroughly examine you to understand your condition.
  • Removing a sample of tissue for testing (biopsy). Your doctor will remove a sample of suspicious tissue for laboratory testing. Analysis in the lab can detect cancer cells and determine certain characteristics of your cancer cells that may help guide your treatment.
  • Imaging tests. Imaging tests can give your doctor an idea of the extent of your cancer. Tests may include MRI, CT and positron emission tomography (PET). Which tests you undergo will depend on your particular situation.


Which angiosarcoma treatment is best for you depends on your cancer's location, its size and whether it has spread to other areas of your body.

Treatment options may include:

  • Surgery. The goal of surgery is to remove the angiosarcoma entirely. Your surgeon will remove the cancer and some of the healthy tissue that surrounds it. In some cases surgery may not be an option, for example, if the cancer is very large or has spread to other areas of the body.
  • Radiation therapy. Radiation therapy uses high-energy beams, such as X-rays and protons, to kill cancer cells. Radiation therapy is sometimes used after surgery to kill any cancer cells that remain. Radiation therapy may also be an option if you can't undergo surgery.
  • Chemotherapy. Chemotherapy is a treatment that uses drugs or chemicals to kill cancer cells. Chemotherapy may be an option if your angiosarcoma has spread to other areas of your body. In certain situations, it may be combined with radiation therapy if you can't undergo surgery.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Preparing for your appointment

If you have signs and symptoms that worry you, start by seeing your family doctor. If your doctor suspects you may have angiosarcoma, you may be referred to a doctor who specializes in skin diseases (dermatologist) or one that specializes in treating cancer (oncologist).

Because appointments can be brief, and because there's often a lot of ground to cover, it's a good idea to be well-prepared. Here's some information to help you get ready, and what to expect from your doctor.

What you can do

  • Be aware of any pre-appointment restrictions. At the time you make the appointment, be sure to ask if there's anything you need to do in advance, such as restrict your diet.
  • Write down any symptoms you're experiencing, including any that may seem unrelated to the reason for which you scheduled the appointment.
  • Write down key personal information, including any major stresses or recent life changes.
  • Make a list of all medications, vitamins or supplements that you're taking.
  • Take a family member or friend along. Sometimes it can be difficult to recall all the information provided during an appointment. Someone who accompanies you may remember something that you missed or forgot.
  • Write down questions to ask your doctor.

Your time with your doctor is limited, so preparing a list of questions can help you make the most of your time together. List your questions from most important to least important in case time runs out. For angiosarcoma, some basic questions to ask your doctor include:

  • How advanced is my angiosarcoma?
  • Has my angiosarcoma spread to other parts of my body?
  • What treatments do you recommend?
  • What are the benefits and risks of each treatment option?
  • I have other health problems. How can I best manage them together?
  • Will I be able to work and do my usual activities during angiosarcoma treatment?
  • Should I seek a second opinion?
  • Should I see a doctor who specializes in cancer treatment?
  • How quickly do I need to make a decision about treatment? Can I take some time to consider my options?
  • Are there any brochures or other printed material that I can take with me? What websites do you recommend?

If any additional questions occur to you during your visit, don't hesitate to ask.

What to expect from your doctor

Your doctor is likely to ask you a number of questions. Being ready to answer them may reserve time to go over points you want to talk about in-depth. Your doctor may ask:

  • When did you first begin experiencing symptoms?
  • Are your symptoms occasional or continuous?
  • How severe are your symptoms?
  • Does anything seem to improve your symptoms?
  • Does anything seem to make your symptoms worse?
  • Have you been diagnosed with any other medical conditions?
  • What medications are you currently taking, including vitamins and supplements?
April 29, 2020
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  2. Bolognia JL, et al, eds. Vascular neoplasms and neoplastic-like proliferations. In: Dermatology. 3rd ed. Philadelphia, Pa.: Elsevier; 2012. https://www.clinicalkey.com. Accessed Jan. 12, 2017.
  3. Soft tissue sarcoma. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Jan. 12, 2017.
  4. Patel SH, et al. Angiosarcoma of the scalp and face: The Mayo Clinic experience. JAMA Otolaryngology — Head & Neck Surgery. 2015;141:335.