Survival rates By Mayo Clinic Staff If anal cancer is caught while it is still small and has not spread, most people can be successfully treated and live many years, often with their usual control of their bowel movements. As the cancer grows deeper into the anal wall or spreads to other parts of the body, the chance of a cure becomes lower. Survival statisticsTo understand survival rates, experts study many people being treated for anal cancer and then report how many are living five years after their diagnosis. Many people expect the anal cancer survival rates to be reported by numbered stages, from 1 to 4. But the U.S. National Cancer Institute (NCI) reports survival rates by how far the cancer has spread. This is called summary staging, and the categories include localized, regional and distant anal cancer. Stage 5-year survival rate Localized: Cancer is only in the anal area. 85% Regional: Cancer has spread to nearby tissues or lymph nodes. 70% Distant: Cancer has spread to distant organs, such as the liver or lungs. 36% Request an appointment StagesDoctors & departments Feb. 03, 2026 Share on: FacebookTwitter Living with anal cancer? Connect with others like you for support and answers to your questions in the Colorectal Cancer support group on Mayo Clinic Connect, a patient community. Colorectal Cancer Discussions New to colon cancer: Don't know my stage yet. What should I ask? 10 Replies Wed, Feb 04, 2026 chevron-right Mayo seeking volunteers: Chemo-Induced Peripheral Neuropathy study 48 Replies Tue, Feb 03, 2026 chevron-right What should I expect with advanced Rectal cancer? 2 Replies Tue, Feb 03, 2026 chevron-right See more discussions Show references Anal carcinoma. National Comprehensive Cancer Network. https://www.nccn.org/patientresources/patient-resources/guidelines-for-patients/guidelines-for-patients-details?patientGuidelineId=58. Accessed Nov. 17, 2025. Palliative care. National Comprehensive Cancer Network. https://www.nccn.org/patientresources/patient-resources/guidelines-for-patients/guidelines-for-patients-details?patientGuidelineId=73. Accessed Nov. 17, 2025. Anal cancer treatment (PDQ)— Health professional version. National Cancer Institute. https://www.cancer.gov/types/anal/hp/anal-treatment-pdq. Accessed Nov. 17, 2025. Gowin K, et al. Integrative therapies in cancer care: An update on the guidelines. American Society of Clinical Oncology Education Book. 2024; doi:10.1200/EDBK_431554. American College of Surgeons. Anus: Protocol for cancer staging documentation. In: AJCC Cancer Staging System. American College of Surgeons; 2025. https://www.facs.org/quality-programs/cancer-programs/american-joint-committee-on-cancer/version-9/. Accessed Nov. 18, 2025. Warner KJ. Allscripts EPSi. Mayo Clinic. May 7, 2019. Cancer stat facts: Anal cancer. National Cancer Institute (NCI) Surveillance, Epidemiology, and End Results (SEER) Program. https://seer.cancer.gov/statfacts/html/anus.htmlAccessed Dec. 22, 2025. Morris VK, et al. Systemic therapy for stage I-III anal squamous cell carcinoma: ASCO guideline. Journal of Clinical Oncology. 2025; doi:10.1200/JCO-24-02120. Accessed Nov. 18, 2025. Willett CG, et al. Clinical presentation, diagnosis, and staging of anal cancer. https://www.uptodate.com/contents/search. Accessed Nov. 18, 2025. DeVita VT Jr, et al., eds. Cancer of the anal region. In: DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology. 12th ed. ProQuest Ebook Central. Wolters Kluwer; 2023. Accessed Nov. 18, 2025. AskMayoExpert. Anal cancer (adult). Mayo Clinic; 2024. Related The anal canal Associated Procedures Chemotherapy Colostomy: Surgery, Bags and Stoma Care CT scan MRI Positron emission tomography scan Radiation therapy Ultrasound X-ray Show more associated procedures Products & Services A Book: Mayo Clinic on Digestive Health Anal cancerSymptoms&causesDiagnosis&treatmentStagesSurvivalratesDoctors&departmentsCare atMayoClinic CON-20198273 Diseases & Conditions Anal cancer