Clinical Trials
Below are current clinical trials.
17 studies in Psychiatry and Psychology (open studies only).
Filter this list of studies by location, status and more.
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Rochester, Minn., Austin, Minn.
16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression
Study type:
Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
IV What is this?
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.
About this study
The FLAME Study is a 16-week clinical trial to study treatment with lamotrigine or fluoxetine in bipolar I, II and bipolar schizoaffective depressed adults. The purpose of the trial is to have a better understanding of whether individuals with a particular gene type and other inherited biological markers will have a good response to fluoxetine or lamotrigine, or alternatively, would be more likely to have side effects to this medication.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Rochester, Minnesota: 13-003545
- Austin, Minnesota: 13-003545
NCT ID:
NCT02389712Sponsor Protocol Number:
13-003545
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Rochester, Minn.
A Study of a Therapeutic Video Game for Social Anxiety in Children
Study type:
Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
About this study
The purpose of this study is to learn if children with social anxiety disorder find a therapeutic video game fun and helpful.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Rochester, Minnesota: 14-000162
NCT ID:
NCT02713425Sponsor Protocol Number:
14-000162
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Rochester, Minn.
Pharmacokinetic Study Comparing Topical, Rectal, and Oral Quetiapine
Study type:
Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
About this study
Quetiapine, a second generation antipsychotic, is only available as oral tablets. However, topical and rectal formulations have been produced in compounding pharmacies. There is no data available suggesting that topical or rectal formulations provide serum levels similar to oral medication. In the clinical setting, when oral administration of quetiapine is not possible (for example, when a patient is extremely ill physically or mentally or both), clinicians and pharmacists have collaborated in such cases and have at times had to administer quetiapine compounded in other dosage formulations such as rectal or topical formulations. Despite clinical effectiveness of these "other" formulations, there are no available studies that have investigated blood levels of the drug other than the oral form. The investigators are therefore designing this pharmacokinetic study to evaluate the the systemic absorption of quetiapine in oral, rectal and topical formulations. If the investigators are able to demonstrate detectable levels from rectal and topical quetiapine formulations compared to the oral form, this knowledge will enhance clinical psychiatric practice by providing a more broad route of administration for quetiapine which is a commonly used drug for psychiatric symptoms.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Rochester, Minnesota: 14-000896
NCT ID:
NCT02131545Sponsor Protocol Number:
14-000896
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Rochester, Minn.
Community Intervention to Reduce Tobacco Use in Pregnant Women
Study type:
Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
About this study
In the southwest region of Alaska where the project takes place, 79% of Alaska Native women smoke cigarettes or use smokeless tobacco (ST) during pregnancy. In addition, pregnancy appears to be a high risk period for initiation of tobacco use, primarily ST, among women reporting no use of tobacco 3 months before pregnancy. Intervention efforts targeting the entire community, not only pregnant women, to address social norms about tobacco use may be effective. Thus, the investigators will evaluate the efficacy of a novel, multi-component, theory-based intervention for reducing tobacco use during pregnancy, incorporating both individually targeted and community level components delivered by female elders "Native Sisters." The intervention builds on effective community and individual-based approaches for tobacco cessation and lay health advisor approaches for cancer prevention among Native American women. As part of the intervention, a social marketing campaign including digital stories and other small media will be developed with community feedback. Individually targeted components will be six 30-40 minute telephone or home-based peer counseling sessions with pregnant women.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Rochester, Minnesota: 13-008824
NCT ID:
NCT02083081Sponsor Protocol Number:
13-008824
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Austin, Minn., Rochester, Minn.
A PK/PD Genetic Variation Treatment Algorithm Versus Treatment As Usual for Adolescent Management Of Depression
Study type:
Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
IV What is this?
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.
About this study
The overall goal of this investigator-initiated trial is to evaluate the impact of platform algorithm products designed to rapidly identify pharmacokinetic (PK) and/or pharmacodynamic (PD) genomic variation on treatment outcome of depression in adolescents. This new technology may have the potential to optimize treatment selection by improving response, minimizing unfavorable adverse events / side effects and increasing treatment adherence
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Austin, Minnesota: 14-005547
- Rochester, Minnesota: 14-005547
NCT ID:
NCT02286440Sponsor Protocol Number:
14-005547
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Rochester, Minn.
Safety and Effectiveness of NeuroStar® Transcranial Magnetic Stimulation (TMS) Therapy in Depressed Adolescents
Study type:
Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
About this study
To evaluate the safety and efficacy of daily, active Neurostar® TMS (when compared with sham treatment) in adolescents meeting criteria for Major Depressive Disorder (MDD).
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Rochester, Minnesota: 15-005219
NCT ID:
NCT02586688Sponsor Protocol Number:
44-02219-000
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Rochester, Minn.
A Study to Develop a Virtual Reality System to Increase Access to Exposure Therapy for Anxiety and Obsessive Compulsive Disorders
Study type:
Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
About this study
The purpose of this study is to develop a low-cost virtual reality system to make exposure therapy more available and accessible for patients with anxiety and obsessive compulsive disorders.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Rochester, Minnesota: 15-008235
NCT ID:
NCT02713516Sponsor Protocol Number:
15-008235
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Rochester, Minn.
Neuropsychological and Behavioral Testing in Young Patients with Cancer
Study type:
Observational What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
About this study
This research trial studies neuropsychological (learning, remembering or thinking) and behavioral testing in younger patients with cancer. Collecting information over time from a series of tests may help doctors develop effective tests to measure neuropsychological and behavioral function of patients with cancer.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Rochester, Minnesota: 09-000348
NCT ID:
NCT00772200Sponsor Protocol Number:
ALTE07C1
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Scottsdale/Phoenix, Ariz.
A Study of the Potential to Establish Cognitive Research Among the African-Americans Living in Peoria, Arizona
Study type:
Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
About this study
The purpose of this study is to objectively assess the potential for a long term program to reduce the risk of cognitive disorders among a specific African-American community.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Scottsdale/Phoenix, Arizona: 15-000881
Sponsor Protocol Number:
15-000881
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Rochester, Minn.
A Study of the Effects of not Allowing Sleep in Addition to the Usual Care of Hospitalized Patients with Major Depression
Study type:
Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
About this study
This study is to learn how effective a night of no sleep, with or without light therapy, is for patients in an inpatient setting who are experiencing Major depression.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Rochester, Minnesota: 13-006903
Sponsor Protocol Number:
13-006903
.