Physical Medicine and Rehabilitation

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study of the Safety of Joint Injected Sc-rAAV2.5IL-1Ra (a Virus Carried Gene Therapy) in Patients with Moderate Knee Osteoarthritis

   Rochester, Minn.

   The purpose of this study is to determine the safety of sc-rAAV2.5IL-1Ra, a gene therapy carried by a virus and delivered by injection into the knee joint of patients with moderate osteoarthritis of the knee.

2. Spinal Cord Injury and Dysfunction Registry: Acute Injury Through Life Long Care

   Rochester, Minn.

   The purpose of this project is to create and implement a Mayo Clinic spinal cord injury registry that allows team members to collect, sort and analyze patient and program information from acute spinal cord injury through lifelong follow-up.  The data will be used both clinically (for program assessment and federally required reporting) and individual research projects (e.g., patient outcomes).

3. A Study to Learn More About the Material Properties of the Arteries in Healthy Individuals

   Rochester, Minn.

   The purpose of this research study is to obtain knowledge of the elastic and viscous components of the material properties of the arteries in healthy individuals. All soft tissues have both elastic and viscous components, and we are trying to quantify these properties arterial vessels. The aim of the study is to evaluate if these properties are unique indicators of cardiovascular health.

4. Autologous, Culture-Expanded Mesenchymal Stromal Cells for Degenerative Disc Disease

   Rochester, Minn.

   To determine the safety and feasibility of autologous, culture-expanded adipose-derived (AD) mesenchymal stromal cells (MSCs) in subjects with painful degenerative disc disease (DDD).

5. Evaluation of a Tele-Language Rehabilitation Program

   Rochester, Minn.

   The aims of this study are to assess the feasibility of and satisfaction with providing a tele-rehabilitation service directed at language disorders in individuals with stroke and measure the change in language function.

6. Adipose Stem Cells for Traumatic Spinal Cord Injury

   Rochester, Minn.

   The purpose of this study is to determine if mesenchymal stem cells (MSC) derived from the fat tissue can be safely administered into the cerebrospinal fluid (CSF) of patients with spinal cord injury. Adipose-derived mesenchymal stem cells (AD-MSCs) have been used in previous research studies at the Mayo Clinic. All subjects enrolled in this study will receive AD-MSC treatment, which is still experimental and is not approved by the U.S. Food and Drug Administration (FDA) for large scale use. However, the FDA has allowed the use of this agent in this research study.

7. Ultrasound Greater Occipital Nerve Block at C2 Level Compared to Landmark-based Greater Occipital Nerve Block

   Rochester, Minn.

   This study will compare the analgesic benefit of a traditional landmark-guided GON block with the ultrasound-guided approach over a four week period in patients with occipital neuralgia or cervicogenic headache.

8. A Study to Understand the Differences of Walking on a Treadmill and Overground in Patients with Parkinson's Disease

   Rochester, Minn.

   The purpose of this study is to compare treadmill walking and over ground walking gait characteristics in people diagnosed with Parkinson’s disease.

9. Study to Determine Accuracy of Medial and Lateral Knee Joint Line Palpation by Physical Therapists using Ultrasound Imaging Verification

   Rochester, Minn.

   The purpose of this study is to determine the accuracy of both medial and lateral knee joint line palpation by examiners with three different levels of physical therapy experience, and to determine the influence of the supine and seated position on knee joint line palpation accuracy.

10. A Study to Evaluate Meniscal Extrusion with and without Medial Knee Unloader Bracing Using Ultrasound

    Minneapolis, Minn.

    The purpose of this study is to quantify medial meniscal extrusion with and without a medial knee unloader brace using ultrasonography in patients with isolated medial knee pain.