Physical Medicine and Rehabilitation

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study of the Safety of Joint Injected Sc-rAAV2.5IL-1Ra (a Virus Carried Gene Therapy) in Patients with Moderate Knee Osteoarthritis

   Rochester, Minn.

   The purpose of this study is to determine the safety of sc-rAAV2.5IL-1Ra, a gene therapy carried by a virus and delivered by injection into the knee joint of patients with moderate osteoarthritis of the knee.

2. Spinal Cord Injury and Dysfunction Registry: Acute Injury Through Life Long Care

   Rochester, Minn.

   The purpose of this project is to create and implement a Mayo Clinic spinal cord injury registry that allows team members to collect, sort and analyze patient and program information from acute spinal cord injury through lifelong follow-up.  The data will be used both clinically (for program assessment and federally required reporting) and individual research projects (e.g., patient outcomes).

3. A Study to Learn More About the Material Properties of the Arteries in Healthy Individuals

   Rochester, Minn.

   The purpose of this research study is to obtain knowledge of the elastic and viscous components of the material properties of the arteries in healthy individuals. All soft tissues have both elastic and viscous components, and we are trying to quantify these properties arterial vessels. The aim of the study is to evaluate if these properties are unique indicators of cardiovascular health.

4. Evaluation of a Tele-Language Rehabilitation Program

   Rochester, Minn.

   The aims of this study are to assess the feasibility of and satisfaction with providing a tele-rehabilitation service directed at language disorders in individuals with stroke and measure the change in language function.

5. A Study to Evaluate Meniscal Extrusion with and without Medial Knee Unloader Bracing Using Ultrasound

   Minneapolis, Minn.

   The purpose of this study is to quantify medial meniscal extrusion with and without a medial knee unloader brace using ultrasonography in patients with isolated medial knee pain.

6. Ultrasound Greater Occipital Nerve Block at C2 Level Compared to Landmark-based Greater Occipital Nerve Block

   Rochester, Minn.

   This study will compare the analgesic benefit of a traditional landmark-guided GON block with the ultrasound-guided approach over a four week period in patients with occipital neuralgia or cervicogenic headache.

7. A Study of Traditional Korean Medicine Effectiveness in Comparison to Non-Surgical Conventional Standard Treatment for Patients with Lumbar Spinal Spondylolisthesis

   Rochester, Minn.

   This research is being done, in a joint-effort between Mayo Clinic and the Mokhuri Oriental Medical Hospital, to evaluate the effectiveness and safety of two different types of non-surgical treatment in patients with symptomatic lumbar spinal spondylolisthesis.

8. Study to Determine Whether Cancer Symptom Control can be Enhanced Using Electronic Health Records

   Rochester, Minn.

   The purpose of this study is to determine whether control of moderate or worse sleep disturbance, pain, anxiety, depression, and fatigue among cancer survivors and patients with cancer will improve quality of life, symptom severity, function, and adherence to cancer treatment, and reduced health care utilization.

9. Medical and Resource Facilitation Intervention After Traumatic Brain Injury

   Rochester, Minn.

   Mayo Clinic's Traumatic Brain Injury (TBI) Model System Center (TBIMSC) will capitalize on longstanding collaborations with the non-profit Minnesota Brain Injury Alliance (MN BIA) and Minnesota Department of Health (MDH) to test a new way of delivering medical and social services. This trial will address chronic unmet needs expressed by individuals with TBI and their families in the U.S. pertaining to the ineffective connection to specialized medical and community resources in the transition from hospital to community-based care, limited access to TBI experts, and lack of primary care provider (PCP) knowledge about the complex needs of individuals with TBI. Target populations for this study are: 1) individuals with TBI eligible for MN BIA provided Resource Facilitation (RF), 2) their families, and 3) their PCPs. This clinical trial will use a theory-driven complex behavioral intervention that integrates the medical-rehabilitation, therapy, and TBI expertise of Mayo's Brain Rehabilitation Clinic (BRC) with MN BIA's highly developed RF program (a free two-year telephone support service offering assistance in navigating life after brain injury). Mayo Clinic's medical-rehabilitation expertise will be integrated with RF services to deliver direct clinical care remotely using telemedicine and other information and communication technology to test whether outcomes over time are better in a group receiving this model of care compared to a group that receives usual care in their communities. Costs between usual care and intervention groups will be compared in collaboration with the MDH. The overarching goal is development of a replicable, sustainable, and cost effective model of telemedicine care that integrates TBIMS Centers and BIAs nationwide and builds TBI expertise and capacity among PCPs.

10. A Study to Evaluate the Effectiveness of Diaphragmatic Breathing on Reflux Symptoms in Outpatients

    Jacksonville, Fla.

    The purpose of this study is to establish if abdominal breathing exercises can reduce symptoms associated with reflux.