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Below are current clinical trials.
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Rochester, Minn.
The purpose of this study is to model the relationship between corneal swelling and cell density and determine how this relationship differs by contact lens type.
The purpose of this study is to evaluate shear wave data and vascular lumen size determined by Contrast-Enhanced Ultrasound (CEUS) in patients undergoing temporal artery biopsy, to determine the sensitivity and specificity of Shear Wave Elastography (SWE) and CEUS for the diagnosis of temporal arteritis, and to determine the impact of pre-operative ultrasound guided mapping on operative time required for temporal artery biopsy.
The purpose of this study is to assess the effectiveness and safety of DE-109 440 µg every 2 months in subjects with active, non-infectious uveitis of the posterior segment of the eye (NIU-PS). There is a 6-month, single-arm, open-label period after completion of the 6-month double- masked, controlled period allows the evaluation of the efficacy and safety of intravitreal injection of DE-109 440 µg every 2 months for longer duration than appropriate for a placebo or sham control.
The purpose of this study is to quantify potential decreases in visual acuity experienced by patients who experience mid-day fogging during scleral lens wear, compare severity of subjectively reported fogging with clinical findings, and to explore the relationship between scleral lens fitting parameters and mid-day fogging.
The goal of this study is to determine optical and visual function through 5 years after Descemet membrane endothelial keratoplasty (DMEK). The study will also determine graft health (corneal endothelial cell loss) and survival through 5 years after DMEK, and factors associated with these outcomes, as well as assess the relationship between optical and anatomical corneal rehabilitation after DMEK.
The purpose of this study is to evaluate the clinical utility of a quantitative test to measure how color saturation appears in patients with diseases of the optive nerve.
The purpose of this study is to determine the proportion with VMT release and MH closure and to assess factors associated with success. Eyes with vitreomacular traction (VMT) and full-thickness macular holes (MH) will be enrolled into a non-randomized cohort treated with pneumatic vitreolysis (PVL).
The purpose of this study is to evaluate the effectiveness of the critical flicker fusion device in distinguishing different kinds of optic neuropathy and visual perception.
The purpose of this study is to determine if pneumatic vitreolysis (PVL) is effective in releasing VMT. Eyes with idiopathic symptomatic vitreomacular traction (VMT) without a macular hole will be randomly assigned to 0.3-mL intraocular gas (C3F8) injection or sham injection.
After surgery to remove the eye, either by enucleation or evisceration, patients have variable levels of pain for several postoperative days. Some patients have almost no discomfort while others require significant amounts of oral narcotics and report pain of 10 out of 10 on a numerical rating scale. The current operative standard is to infiltrate the eye socket with 0.5% bupivacaine during surgery leading to several hours of postoperative analgesia. In 2011, Pacira Pharmaceuticals released a bupivacaine liposomal injectable suspension (Exparel, 1.3%) which offers sustained release of bupivacaine giving postoperative pain control for up to 72 hours. This medication has been used in numerous surgeries including inguinal hernia repair, hemorrhoidectomy, bunionectomy, breast reconstruction, and orthopedic surgery, and the literature reports improved pain control, decreased use of oral opioids, and increased patient satisfaction. There are no reports of the use of Exparel in the ophthalmic literature. The investigators propose a randomized, controlled trial to compare the postoperative pain control offered by sustained release bupivacaine to that offered by standard plain bupivacaine after enucleation or evisceration.