Ophthalmology

Below are current clinical trials.

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1. A Study to Evaluate Patient Reported Outcome Measures in Children with Eye Conditions

   Rochester, Minn.

   The objectives of this study are:

   • To evaluate patient-reported quality of life and functional vision across the spectrum of pediatric eye conditions;
   • To assess change in patient-reported quality of life and functional vision over time;
   • To compare the impact of different treatments on quality of life and functional vision;
   • To assess change in patient-reported quality of life and functional vision in response to treatment;
   • To determine associations between quality of life / functional vision scores and specific clinical and demographic characteristics.

2. A Study to Evaluate a Color Test for Patients with Optic Nerve Diseases

   Rochester, Minn.

   The purpose of this study is to evaluate the clinical utility of a quantitative test to measure how color saturation appears in patients with diseases of the optive nerve.

3. Exparel Injection for Postoperative Orbital Pain

   Rochester, Minn.

   After surgery to remove the eye, either by enucleation or evisceration, patients have variable levels of pain for several postoperative days. Some patients have almost no discomfort while others require significant amounts of oral narcotics and report pain of 10 out of 10 on a numerical rating scale. The current operative standard is to infiltrate the eye socket with 0.5% bupivacaine during surgery leading to several hours of postoperative analgesia. In 2011, Pacira Pharmaceuticals released a bupivacaine liposomal injectable suspension (Exparel, 1.3%) which offers sustained release of bupivacaine giving postoperative pain control for up to 72 hours. This medication has been used in numerous surgeries including inguinal hernia repair, hemorrhoidectomy, bunionectomy, breast reconstruction, and orthopedic surgery, and the literature reports improved pain control, decreased use of oral opioids, and increased patient satisfaction. There are no reports of the use of Exparel in the ophthalmic literature. The investigators propose a randomized, controlled trial to compare the postoperative pain control offered by sustained release bupivacaine to that offered by standard plain bupivacaine after enucleation or evisceration.

4. A Study to Evaluate Optical Coherence Tomography (OCT) and OCT Angiography (OCTA) Imaging In Supine Patient

   Rochester, Minn.

   The purpose of this study is to determine if a relay lens and right angle mirror can be used in conjunction with an FDA-approved optical coherence tomography (OCT) unit to allow imaging in supine patients.

5. A Study Randomized Trial to Evaluate Sequential vs Simultaneous Spectacles Plus Patching for Amblyopia in Children 3 to < 13 Years Old

   Rochester, Minn.

   The purpose of this study is to determine whether simultaneous treatment with spectacles and patching has an equivalent VA outcome compared with sequential treatment, first with spectacles alone, followed by patching (if needed), for previously untreated amblyopia in children 3 to < 13 years of age.

    

    

6. A Study to Evaluate Visual Function in Fuchs Endothelial Corneal Dystrophy

   Rochester, Minn.

   The purpose of this study is to determine visual function in patients with Fuchs Endothelial Corneal Dystrophy (FECD) to understand when in the course of disease patients are affected by compromised vision.

7. Evaluating Optic Nerve Disease with OCT Angiography

   Rochester, Minn.

   The purpose of this study is to determine if optical coherence tomography (OCT) angiography is able to distinguish different causes of optic neuropathy.

8. A Study to Analyze Waste Specimens from the Eye After Surgery

   Rochester, Minn.

   The purpose of this study is to learn about cell function in different tissues of the eye in various ocular diseases via transcriptomics in the Mayo Clinic laboratory.

9. Collaborative Study on Optic Neuritis and Autoantibodies Affecting the Eye

   Rochester, Minn.

   The study proposes to form a consortium of autoimmunity of the optic nerve with the goal of improving diagnosis and treatment of these conditions. 

10. A Study to Evaluate the Use of Micropulse Trans-Scleral Cyclophotocoagulation Laser (MP-TSCPC) for Glaucoma Patients

    Jacksonville, Fla.

    The purpose of this study is to evaluate the clinical outcomes of the Micropulse Trans-Scleral Cyclophotocoagulation Laser (MPTSCPC) after 1 day, 1 week,1 month, 3 months, 6 months and one year of follow-up. Its primary objective is to conduct a prospective observational study on the efficacy of using MP-TSCPC to treat glaucoma patients.