Gastroenterology and Hepatology

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study to Assess the Safety and Tolerability of Single and Multiple Doses of KAN-101 in Celiac Disease Patients

   Rochester, Minn.

   The purpose of this study is to assess the safety and tolerable of single and multiple doses of KAN-101 in patients with Celiac disease.

2. Tissue Collection for Patients with Cancers other than Hepatobilairy Cancers with Metastasis to the Liver

   Rochester, Minn.

   The goal of this study is to develop a resource (bank) of biospecimens (blood, tissue) from patients having cancers that metastasis to the liver. The purpose of the resource bank is to facilitate studies on the pathogenesis of cancers metastasizing to the liver and also in order to assess the ability of new tests to detect early cancer in the cohort of patients undergoing routine surveillance for cancer. The biospecimens will include cultures of tumor cells and tumor-associated non-malignant cells, as well as xenografts established from freshly isolated metastatic cancers in immunodeficient mice. We plan to administer a risk factor questionnaire to facilitate identification of risk factors for development of metastatic liver cancer. The study will also  determine survival of patients from time of diagnosis.

    

3. Whole Exome Sequencing and Other Emerging Technologies of Endoscopic Ultrasound Cytopathology

   Rochester, Minn.

   The purpose of this research study is to gather information on the feasibility of performing novel molecular analysis on Endoscopic Ultrasound acquired cytologic material and to assess molecular changes in cytology samples to see if that may aid treatment decision planning for future patients.

4. Transforming Non-Invasive Liver Disease Detection by Magnetic Resonance Elastography

   Rochester, Minn.

   A variety of liver insults lead to pathological changes in liver architecture that culminate in cirrhosis. While invasive liver biopsy was required to detect cirrhosis, the development of magnetic resonance elastography (MRE) has revolutionized our ability to detect liver fibrosis through non-invasive means that involve measurement of liver stiffness. However, a number of pathological findings occur in liver in response to various insults that precede cirrhosis and are clinically important to identify such as steatosis associated with NASH, inflammation associated with viral hepatitis, and congestion associated with cardiac hepatopathy. Detection of such entities provides essential diagnostic, prognostic, and treatment information but yet is not available non-invasively. Recent murine studies from this group of investigators has identified that MRE technology can be adapted to non-invasively detect these conditions. Implementing this into the practice will transform it by obviating the need for invasive liver biopsies in patients suspected of having such forms of suspected liver disease. This will differentiate Mayo from other institutions where such technology is not available.

   An additional aim of this study is to examine the impact of obstructive sleep apnea (OSA) on the pathogenesis of nonalcoholic fatty liver disease (NAFLD), both common comorbidities of obesity. Recent evidence indicates a potential link between OSA and severity of NASH and fibrosis, but the mechanisms of OSA- associated hypoxia on liver disease progression in NAFLD is unclear. This study offers the unique opportunity to analyze this association, as the study population will undergo routine evaluation for OSA, as part as the preoperative work-up prior to bariatric surgery.

5. Cystic Kidney and Liver Disease Biobank

   Rochester, Minn.

    

   This research study is being done to create a collection of biospecimens (blood, urine, cyst fluid, bile, kidney or liver tissue, etc.) that can be used to facilitate the conduction of research on polycystic kidney and/or liver disease.

6. A Study to Evaluate Voice-enabled Artificial Intelligence to Diagnosis Hepatic Encephalopathy

   Rochester, Minn.

   early detection of hepatic encephalopathy

7. Adipose Derived Stromal Vascular Fraction for Aero-digestive & Enterocutaneous Fistulae

   Jacksonville, Fla.

   The purpose of this study is to evaluate the feasibility, time, cost, safety, limitations, and efficacy of the use of institutionally processed SVF for management and closure of aero-digestive and enterocutaneous fistulae.

8. A Study to Assess the BioTraceIO System for Identifying Tissue Damage from Microwave Thermal Liver Ablation

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to evaluate the accuracy of the BioTrace IO during RFA/MWA Transcutaneous procedures.

9. Fecal Microbiome Transplant National Registry

   Rochester, Minn.

   The overarching goal of the FMT registry is to expand knowledge and optimize practice in the transplantation of fecal microbiota or other gut-related-microbiota products.

10. Biobank for Cholestatic Liver Diseases

    Rochester, Minn.

    This study is a biobank of specimens and clinical data for use in current and future research to better understand the cholestatic liver diseases primary biliary cirrhosis/cholangitis (PBC) and primary sclerosing cholangitis (PSC).