Dermatology

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study to Collect Long-Term Data on Pediatric Cutaneous Mastocytosis

   Rochester, Minn.

   The purpose of this study is to develop a registry to collect long-term data on patients with pediatric cutaneous mastocytosis, and develop better knowledge of the timing, symptoms, resolution or progression of the disease, and predictive markers of its severity.

2. Oncogene-­-Induced Secretion of Extracellular Matrix Proteins in Squamous Cell Carcinoma of the Skin

   Rochester, Minn.

   The purpose of this study is:

   Define a set of differentially regulated secreted proteins in human cancer cells across all stages of cancer progression

   • Identify a set of 32 genes (including housekeeping genes) that encode for secreted proteins that correlate with disease progression using a bioinformatics approach
   • Design probe sets for RT-PCR and run a pilot study both on FFPE and fresh tissue
   • If the pilot is successful, expand the data set to an n of 100. Include SCCs of various differentiation and anatomical location. Include SCCs from transplant patients.

   Correlate the results of the RT-PCR panel to the biological behavior of the tumor

   • The following variables will be examined:
     • Differentiation
     • Ability to metastasize
     • Response to therapy

3. Development of an Evidence-Based Decision Aid for Acne Treatment

   Rochester, Minn.

   The purpose of this study is to identify the key elements of the clinical discussion between patients and clinicians regarding acne treatment and to develop an evidence-based decision aid for acne treatment. 

4. Patient Satisfaction in Mohs Micrographic Surgery with Supplemental Lidocaine Jelly

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to assess how using lidocaine jelly in Mohs surgery impacts 1) the overall quantity of lidocaine/epinephrine injectable needed to maintain anesthesia, and 2) patients’ pain/anxiety associated with anesthesia injections.   

5. A Study of Phenotypic and Genetic Analysis of Vascular Overgrowth Syndromes

   Rochester, Minn.

   The purpose of this research is to develop a better understanding of the cause of vascular overgrowth syndromes and to develop a clinically relevant classification system. The researchers will also seek to determine if there is a relationship between the specific gene mutation and the clinical features (genotype-phenotype correlation).

6. A Study to Evaluate The Effectiveness and Safety of Abrocitinib, with or without Topical Medications, in Subjects Aged 12 Years and Older with Moderate-to-Severe Atopic Dermatitis

   Rochester, Minn.

   The purpose of this extension study is to evaluate the effectiveness and safety of two dosage strengths of PF-04965842, 100 mg and 200 mg taken orally once daily, over approximately two years of study participation. Patients who meet safety step-down criteria will have their dose reduced once, from 200 mg QD to 100 mg QD, or from 100 mg QD to placebo.

7. A Study of Cemiplimab in Patients With Advanced Basal Cell Carcinoma Who Experienced Progression of Disease on Hedgehog Pathway Inhibitor Therapy, or Were Intolerant of Prior Hedgehog Pathway Inhibitor Therapy

   Scottsdale/Phoenix, Ariz., Jacksonville, Fla., Rochester, Minn.

   The primary objective is to estimate the overall response rate (ORR) for metastatic Basal Cell Carcinoma (BCC) (group 1) and for unresectable locally advanced BCC (group 2) when treated with Cemiplimab as a monotherapy.

8. Evaluating the Effectiveness of Apremilast in the Treatment of Subjects with Canker Sores

   Jacksonville, Fla.

   The purpose of this study is to determine whether Apremalast is an effective treatment for patients with recurring canker sores.

9. A Study to Evaluate Intravenous Iloprost in Subjects with Symptomatic Raynaud's Phenomenon Secondary to Systemic Sclerosis

   Rochester, Minn.

   The purpose of this study is to evaluate the safety and effectiveness of iloprost on the frequency of and relief from symptomatic digital ischemic episodes in subjects with systemic sclerosis.

10. A Study of PRN1008 in Patients With Pemphigus

    Rochester, Minn.

    The purpose of this study is to evaluate the effectiveness and safety of oral PRN1008 in moderate to severe pemphigus.