Dermatology

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Hypertrophic Scar Prevention by Novel Topical Gel Application

   Rochester, Minn.

   Researchers are trying to find out more about the side effects of topical (applied to the skin) Pentamidine, to determine if it is safe for use in people. They also want to find out if topical use of Pentamidine can help treat hypertrophic scars. Pentamidine is a medicine that is currently used to treat certain kinds of infection. It is most often given by intravenous (into a vein) or inhalation (through a breathing device). This medication is approved by the U.S. Food and Drug Administration (FDA) for use in these forms. Everyone in this study will receive topical Pentamidine (TP) in a silicone based gel (PCCA Pracasil Plus). Topical treatment of Pentamidine is still experimental and has not been formally tested for safety or effectiveness in a randomized control trial within the United States. The FDA has allowed the use of topical Pentamidine in this research study.

2. A Study of Bone Health in Patients with Overgrowth Syndromes

   Rochester, Minn.

   The goal of this study is to determine whether or not patients with overgrowth syndromes have decreased bone density.

3. Oncogene-­-Induced Secretion of Extracellular Matrix Proteins in Squamous Cell Carcinoma of the Skin

   Rochester, Minn.

   The purpose of this study is:

   Define a set of differentially regulated secreted proteins in human cancer cells across all stages of cancer progression

   • Identify a set of 32 genes (including housekeeping genes) that encode for secreted proteins that correlate with disease progression using a bioinformatics approach
   • Design probe sets for RT-PCR and run a pilot study both on FFPE and fresh tissue
   • If the pilot is successful, expand the data set to an n of 100. Include SCCs of various differentiation and anatomical location. Include SCCs from transplant patients.

   Correlate the results of the RT-PCR panel to the biological behavior of the tumor

   • The following variables will be examined:
     • Differentiation
     • Ability to metastasize
     • Response to therapy

4. Efficacy, Safety and Pharmacokinetics of Topical Timolol in Infants With Infantile Hemangioma (IH)

   Rochester, Minn.

   Multi-center, double-masked randomized, efficacy, safety and pharmacokinetic (PK) study.

5. Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients with Stage IV Melanoma that Cannot be Removed by Surgery

   Rochester, Minn.

   This phase I trial studies the side effects and best dose of paclitaxel albumin-stabilized nanoparticle formulation and bevacizumab in treating patients with stage IV melanoma that cannot be removed by surgery. Drugs used in chemotherapy, such as paclitaxel albumin-stabilized nanoparticle formulation, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Giving paclitaxel albumin-stabilized nanoparticle formulation and bevacizumab many kill more tumor cells.

6. Trial of Educational Modification Sessions and Sunless Tanner AS A Method of Reducing the Incidence of Tanning Bed Use in Young Adults

   Rochester, Minn.

   This phase II four armed factorial randomized clinical trial will look at tanning bed use reduction in the setting of skin cancer directed educational sessions in young adults with frequent tanning bed use. It is hoped that the experimental treatment of education sun safety sessions and free sunless tanner samples will be successful in decreasing the mean frequency of tanning bed use.  In addition to tanning bed use reduction, this trial will also determine tanning bed use abstinence and compare the frequent application of sun screen in addition to other healthy habits among participants.

    

7. Collecting Blood and Tissue Samples From Family Members of Patients With Pancreatic Diseases, Pancreatic Cancer, and Melanoma

   Rochester, Minn.

   RATIONALE: Collecting and storing samples of blood and tissue from family members of patients with cancer to test in the laboratory may help the study of cancer in the future. PURPOSE: This clinical trial is collecting blood and tissue samples from family members of patients with pancreatic disease, pancreatic cancer, and melanoma.

8. Self-assessment of Change in Hair Quality and Lifestyle Factors in Cicatricial Alopecia Patients

   Rochester, Minn.

   Little is known about the natural history of cicatricial alopecia (CA), including baseline hair characteristics, etiology, risk factors and time course. Therefore this study seeks to design a questionnaire-based study that will explore these specific questions with the goal of learning more about this disease.

9. Patient Satisfaction in Mohs Micrographic Surgery with Supplemental Lidocaine Jelly

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to assess how using lidocaine jelly in Mohs surgery impacts 1) the overall quantity of lidocaine/epinephrine injectable needed to maintain anesthesia, and 2) patients’ pain/anxiety associated with anesthesia injections.   

10. Adipose-Derived Stromal Cells (ASC's) and Pressure Ulcers

    Jacksonville, Fla.

    This pilot study of 12 patients (6 control, 6 experimental) will test the safety and efficacy of applying autologous, adipose-derived stromal cells (ASCs), uncultured, on a Stage III or IV pressure ulcer. Patients in both groups would undergo a minimal risk liposuction procedure to withdraw 50-100 cc of adipose tissue. The tissue would be processed to extract the stromal layer of cells that contain stem cells. The ASCs would be injected into a fibrin sealant to be applied to the wound. Patients would be followed for 6 weeks to assess wound healing and tolerance of the treatment.