Breadcrumb < Timeline 1963Measles History of measles: Outbreaks and vaccine timeline Learn about the development, approval and impact of the measles vaccine. Measles virus The measles virus that causes measles 1954 Drs. John F. Enders and Thomas C. Peebles isolate the measles virus, called the Edmonston strain, in tissue. It’s used to develop many other vaccines. 1963 Dr. Enders and his colleagues develop the live attenuated Edmonston B measles vaccine. This vaccine and a second measles vaccine are licensed in 1963. Two other live attenuated measles vaccines will be licensed in 1965 and 1968. More than 500,000 cases of measles occurred each year in the U.S. in the 20th century compared with 13 cases in 2020. 1971 The measles, mumps and rubella vaccines are combined into the measles-mumps-rubella (MMR) vaccine in the U.S. 2000 Measles is considered eliminated in the U.S. Learn more Infectious Diseases A-Z: Battling a myth about measles vaccine Infectious Diseases A-Z: Breaking down the MMR vaccine Show references Plotkin SA, et al., eds. Plotkin’s Vaccines. 7th ed. Elsevier; 2018. https://www.clinicalkey.com. Accessed Oct. 8, 2021. Blake JB. Benjamin Waterhouse and the introduction of vaccination. Reviews of Infectious Diseases. Oxford University Press. 1987;doi:10.1093/clinids/9.5.1044. Desmond A, et al. On the shoulders of giants — From Jenner’s cowpox to mRNA Covid vaccines. The New England Journal of Medicine. 2021; doi:10.1056/NEJMp2034334. Saleh A, et al. Vaccine development throughout history. Cureus. 2021; doi:10.7759/cureus.16635. The history of vaccines. 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