Yulian Zhao, M.D., Ph.D.

  1. Bioanalyst


  1. Poojary PS, Nayak G, Panchanan G, Rao A, Kundapur SD, Kalthur SG, Mutalik S, Adiga SK, Zhao Y, Bakkum-Gamez J, Chang AY, DeStephano C, Sherman M, Kannan N, Kalthur G. Distinctions in PCOS induced by letrozole versus dehydroepiandrosterone with high-fat diet in mouse model. Endocrinology. 2022 Jul 1 Epub 2022 July 01
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  2. Miller CM, Duong S, Weaver AL, Zhao Y, Shenoy CC. Outcomes of Frozen Oocyte Donor In Vitro Fertilization (IVF) Cycles Using Fresh Versus Frozen Sperm. Reprod Sci. 2022 Apr; 29 (4):1226-1231 Epub 2021 Nov 23
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  3. Sadecki E, Weaver A, Zhao Y, Stewart EA, Ainsworth AJ. Fertility trends and comparisons in a historical cohort of US women with primary infertility. Reprod Health. 2022 Jan 18; 19 (1):13
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  4. Dcunha R, Hussein RS, Ananda H, Kumari S, Adiga SK, Kannan N, Zhao Y, Kalthur G. Current Insights and Latest Updates in Sperm Motility and Associated Applications in Assisted Reproduction. Reprod Sci. 2022 Jan; 29 (1):7-25 Epub 2020 Dec 07
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  5. Miller CM, Weaver AL, Zhao Y, Babayev SN. Outcomes of embryo transfers performed by Reproductive Endocrinology and Infertility fellows vs. faculty: an 11-year retrospective review. Fertil Steril. 2022 Jan; 117 (1):115-122 Epub 2021 Sept 20
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  6. Sadecki E, Rust L, Walker DL, Fredrickson JR, Krenik A, Kim T, Weaver AL, Zhao Y. Comparison of live birth rates after IVF-embryo transfer with and without preimplantation genetic testing for aneuploidies. Reprod Biomed Online. 2021 Dec; 43 (6):995-1001 Epub 2021 Sept 21
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  7. Joshi VB, Behl S, Pittock ST, Arndt CAS, Zhao Y, Khan Z, Granberg CF, Chattha A. Establishment of a Pediatric Ovarian and Testicular Cryopreservation Program for Malignant and Non-Malignant Conditions: The Mayo Clinic Experience. J Pediatr Adolesc Gynecol. 2021 Oct; 34 (5):673-680 Epub 2021 Apr 25
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  8. Neblett MF 2nd, Kim T, Jones TL, Baumgarten SC, Coddington CC, Zhao Y, Shenoy CC. Is there still a role for a cleavage-stage embryo transfer? F S Rep. 2021 Sep; 2 (3):269-274 Epub 2021 June 29
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  9. Hussein RS, Zhao Y, Khan Z. Does type of cancer affect ovarian response in oncofertility patients? J Gynecol Obstet Hum Reprod. 2021 Jun; 50 (6):101944 Epub 2020 Oct 15
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  10. Hussein RS, Elnashar I, Amin AF, Zhao Y, Abdelmagied AM, Abbas AM, Abdelaleem AA, Farghaly TA, Abdalmageed OS, Youssef AA, Badran E, Abou-Taleb HA. Effect of Metformin on Premature Luteinization and Pregnancy Outcomes in Intracytoplasmic Sperm Injection-Fresh Embryo Transfer Cycles: A Randomized Double-Blind Controlled Trial. Int J Fertil Steril. 2021 Apr; 15 (2):108-114 Epub 2021 Mar 11
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  11. Behl S, Joshi VB, Hussein RS, Walker DL, Lampat KL, Krenik AG, Barud KM, Fredrickson JR, Galanits TM, Rian KJ, Delgado AM, Byrne JH, Potter D Jr, Pittock ST, Arndt CAS, Zhao Y, Gargollo PC, Granberg CF, Khan Z, Chattha AJ. Consult and procedure incidence outcomes following establishment of a fertility preservation program for children with cancer. J Assist Reprod Genet. 2021 Feb; 38 (2):495-501 Epub 2021 Jan 03
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  12. Hussein RS, Elnashar I, Abou-Taleb HA, Zhao Y, Abdelmagied AM, Abbas AM, Abdalmageed OS, Abdelaleem AA, Farghaly TA, Youssef AA, Badran E, Ibrahim MN, Amin AF. Progesterone/Oestradiol ratio can Better Predict Intracytoplasmic Sperm Injection Outcomes than Absolute Progesterone Level. J Hum Reprod Sci. 2021 Jan-Mar; 14 (1):28-35 Epub 2021 Mar 30
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  13. Kim T, Kim Y, Lucien F, Zhao Y, Enninga EAL. Decreased gremlin 1 expression in women with BMI >/=35 kg/m(2) is mediated by interleukin 10 and interleukin 1beta in the follicular fluid. F S Sci. 2020 Aug; 1 (1):16-26 Epub 2020 June 29
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  14. Hussein RS, Khan Z, Zhao Y. Fertility Preservation in Women: Indications and Options for Therapy. Mayo Clin Proc. 2020 Apr; 95 (4):770-783
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  15. Hussein RS, Elnashar I, Amin AF, Abou-Taleb HA, Abbas AM, Abdelmageed AM, Farghaly T, Zhao Y. Revisiting debates of premature luteinization and its effect on assisted reproductive technology outcome. J Assist Reprod Genet. 2019 Nov; 36 (11):2195-2206 Epub 2019 Oct 25
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  16. Christianson MS, Shoham G, Tobler KJ, Zhao Y, Monseur B, Leong M, Shoham Z. Use of various gonadotropin and biosimilar formulations for in vitro fertilization cycles: results of a worldwide Web-based survey. J Assist Reprod Genet. 2017 Aug; 34 (8):1059-1066 Epub 2017 June 01
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  17. Londra L, Moreau C, Strobino D, Bhasin A, Zhao Y. Is the type of GnRH suppression protocol for ovarian hyperstimulation associated with ectopic pregnancy in fresh autologous cycles for in vitro fertilization? Fertility and Sterility .2016;106:(3):666-672.
  18. Lai TH, Vlahos N, Shih IM, Zhao Y. Expression Patterns of VEGF and Flk-1 in Human Endometrium during the Menstrual Cycle. J Reprod Infertil.2015;16:(1):3-9.
  19. Christianson MS, Wu H, Zhao Y, Yemini M, Leong M, Shoham Z. Metformin use in patients undergoing in vitro fertilization treatment: results of a worldwide web-based survey. J Assist Reprod Genet.2015;32:(3):401-406.
  20. Tobler KJ, Zhao Y, Ross R, Benner AT, Xu X, Du L, Broman K, Thrift K, Brezina PR, Kearns WG. Blastocoel fluid from differentiated blastocysts harbors nuclei capable of a whole genome DNA amplification and comprehensive chromosome microarray analysis. Fertility and Sterility.2015;104:(2):418-425.
  21. Londra L, Moreau C, Strobino D, Garcia J, Zacur H, Zhao Y. Ectopic pregnancy after in vitro fertilization: differences between fresh and frozen-thawed cycles. Fertility and Sterility.2015;104:(1):111-118.
  22. Christianson MS, Shoham G, Tobler KJ, Zhao Y, Cordeiro CN, Leong M, Shoham Z. Measurement of Antral Follicle Count in Patients Undergoing In Vitro Fertilization Treatment: Results of a Worldwide Web-based Survey. J Assist Reprod Genet.2015;32:(10):1435-1440.
  23. Tobler KJ, Shoham G, Christianson MS, Zhao Y, Leong M, Shoham Z. The use of antimullerian hormone for testing ovarian reserve reported from 796 IVF clinics throughout the world. J Assist Reprod Genet.2015;32:(10):1441-1448.
  24. Tobler KJ, Brezina P, Garcia JE, Zhao Y. Sibling oocytes randomly assigned to either conventional fertilization or intracytoplasmic sperm injection demonstrate equivalent fertilization and blastulation rates. JFIV Reprod Med Genet .2014;2:1-6.
  25. Londra L, Wallach E, Zhao Y. Assisted reproduction: Ethical and legal issues. Seminars in Fetal & Neonatal Medicine.2014;19:(5):264-271.
  26. Tobler KJ, Zhao Y, Weissman A, Leong M, Shoham Z. World-wide survey of IVF practices: trigger, retrieval and embryo transfer techniques. Archives of Gynecology and Obstetrics.2014;290:(3):561-568.
  27. Christianson MS, Zhao Y, Shoham G, Granot I, Safran A, Khafagy A, Leong M, Shoham Z. Embryo catheter loading and embryo culture techniques: results of a worldwide web-based survey. J Assist Reprod Genet.2014;31:(8):1029-1036.
  28. Ning N, Balen A, Brezina PR, Leong M, Shoham Z, Wallach EE, Zhao Y. How to recognize PCOS: results of a web-based survey at IVF-worldwide.com. Reproductive BioMedicine Online.2013;26:(5):500-505.
  29. Brezina PR, Mensah V, Balen A, Leong M, Weissman A, Zhao Y, Shoham Z. Fertility management in the PCOS population: results of a web-based survey at IVF-worldwide.com. Journal of Assisted Reproduction and Genetics.2013;30:(97):1169-1174.
  30. Brezina PR, Zhao Y. The ethical, legal, and social issues impacted by modern assisted reproductive technologies. Obstetrics and Gynecology International.2012;2012:1-7.
  31. Brezina PR, Yunus FN, Zhao Y. The effects of pharmaceutical medications on male fertility. Journal of Reproduction and Infertility.2012;13 :(1):3-11.
  32. Brezina PR, Ning N, Mitchell E, Zacur HA, Baramki TA, Zhao Y. Recent advances in assisted reproductive technology. Current Obstetrics and Gynecology Reports.2012;1:166-173.
  33. Brezina PR, Vlahos N, Lai TH, Garcia J, Wallach EE, Zhao Y. The impact of luteal phase support on endometrial estrogen and progesterone receptor expression: a randomized control trial. Reproductive Biology and Endocrinology.2012;10:(16):1-6.
  34. Zhao Y, Zacur H, Cheadle C, Ning N, Fan J, Vlahos NF. Effect of luteal-phase support on endometrial microRNAs expression following controlled ovarian stimulation. Reproductive Biology and Endocrinology.2012;10:(72):1-12.
  35. Brezina PR, Yunus F, Garcia J, Zhao Y. Description of the parasite Wucheria Bancrofti Microfilariae identified in follicular fluid following transvaginal oocyte retrieval. Journal of Assisted Reproduction and Genetics.2011;28:(5):433-436.
  36. Yates M, Kolmakova A, Zhao Y, Rodriguez A. Clinical impact of scavenger receptor class B type I gene polymorphisms on human female fertility. Human Reproduction.2011;26:(7):1910-1916.
  37. Zhao Y, Brezina P, Hsu CC, Garcia J, Brinsden P, Wallach E. In Vitro Fertilization: four decades of reflections and promises. Biochimica et Biophysica Acta.2011;1810:(9):843-852.
  38. Zhao Y, Brezina PR. Therapeutic medications and male fertility (Editorial commentary) Journal of Fertilization: In Vitro.2011;1 :(1 ):e104.
  39. Brezina P, Zhao Y. Laser assisted zona hatching: what is the evidence to justify its use? Middle East Fertility Society Journal.2011;16:107-113.
  40. Tang SS, Gao H, Zhao Y, Ma S. Aneuploidy and DNA Fragmentation in Morphologically Abnormal Sperm. International Journal of Andrology.2010;33:(1):e163-179.
  41. Vlahos N, Gregoriou O, Deliveliotou A, Perrea D, Zhao Y, Lai, Creatsas G. The effect of pentoxifylline on VEGF-C and flk-1 expression on endometrial implants in the rat endometriosis model. Fertility and Sterility.2010;93:(4):1316-1323.
  42. Zhao Y, Garcia J, Kolp L, Cheadle C, Rodriguez A, Vlahos NF. The impact of luteal phase support on gene expression of extracellular matrix protein and adhesion molecules in the human endometrium during the window of implantation following controlled ovarian stimulation with a GnRH antagonist protocol. Fertility and Sterility.2010;94:(6):2264-2271.
  43. Lipari CW, Garcia JE, Zhao Y, Thrift K, Vaidya D, Rodriguez A. Nitric oxide metabolite production in the human preimplantation embryo and successful blastocyst formation. Fertility and Sterility.2009;91:(4):1316-1318.
  44. Lipari CW, Zhao Y, King JA, Alexander CJ, Bankowski BB, Lai TH, Garcia J, Vlahos NP. Variations in L-selectin Ligand expression in the luteal phase endometrium after final oocyte maturation with human chorionic gonadotropin compared with a gonadotropin-releasing hormone agonist. Fertility and Sterility.2008;90:(3):876-878.
  45. Lai TH, King J, Shih IM, Vlahos N, Zhao Y. Immunological localization of Syndecan-1 in human endometrium throughout the menstrual cycle. Fertility and Sterility.2007;87:(1):121-126.
  46. Ma S, Phillipp T, Zhao Y, Stetten G, Robinson WP, Kalousek D. Frequency of chromosomal abnormalities in the spontaneous abortions derived from intracytoplasmic sperm injection compared with those from in vitro fertilization. Fertility and Sterility.2006;85:(1):236-239.
  47. Lai TH, Zhao Y, Shih IM, Ho CL, Bankowski B, Vlahos N. Expression of L-selectin ligands in human endometrium during the implantation window following controlled ovarian stimulation for oocyte donation. Fertility and Sterility.2006;85:(3):761-763.
  48. Velasco M, Alexander C King J, Zhao Y, Garcia J, Rodriguez A. Association of lower plasma estrodiol levels and low expression of scavenger receptor class B type I in infertile women. Fertility and Sterility.2006;85:(5):1391-1397.
  49. Vlahos NF, Lipari CW, Bankowski BJ, Lai TH, King JA, Shih IM, Frangakis C, Zhao Y. The effect of luteal phase support on endometrial L-selectin ligand expression after recombinant follicle stimulating hormone and ganirelix acetate for in vitro fertilization. Journal Clinical Endocrinology Metabolism.2006;91:(10):4043-4049.
  50. Lai TH, Shih IM, Vlahos N, Ho CL, Wallach E, Zhao Y. Differential expression of L-selectin ligands in the endometrium during the menstrual cycle. Fertility and Sterility.2005;83:(Suppl 1):1297-1302.
  51. Vlahos NF, Coker L, Lawler C, Zhao Y, Bankowski B, Wallach EE. Women with ovulatory dysfunction undergoing ovarian stimulation with clomiphene citrate for intrauterine insemination may benefit from administration of human chorionic gonadotropin. Fertility and Sterility.2005;83:(5):1510-1516.
  52. Vlahos NF, Bankowski BJ, Zacur HA, Garcia JE, Wallach EE, Zhao Y. An oocyte donation protocol using the GnRH antagonist ganirelix acetate does not compromise embryo quality and is associated with high pregnancy rates. Archives of Gynecology and Obstetrics.2005;272:(1):1-6.
  53. Petrella C, Hsieh J, Thrift K, Jarow JP, Zacur H, Zhao Y. Optimizing incubation conditions for the preservation of sperm motility in processed semen samples. Fertility and Sterility.2005;84:(2):513-515.
  54. Jurema M, Vieira A, Bankowski B, Petrella C, Zhao Y, Wallach E, Zacur H. Effect of ejaculatory abstinence period on pregnancy rate after intrauterine insemination. Fertility and Sterility.2005;84:(3):678-681.
  55. Zhao Y, Vlahos N, Wyncott D, Petrella C, Garcia J, Zacur H, Wallach EE. Impact of semen characteristics on the success of intrauterine insemination. Journal of Assisted Reproduction and Genetics.2004;21:(5):143-148.
  56. Zhao Y, Garcia J, Jarow JP, Wallach EE. Successful management of infertility due to retrograde ejaculation using assisted reproductive technologies (ART): a report of two cases. Archives Andrology.2004;50:(6):391-394.
  57. Zhao Y, Kreger DO, Brannian JD. Serum leptin concentrations in women during gonadotropin stimulation cycles. The Journal of Reproductive Medicine.2000;45:(2):121-125.
  58. Zhao Y, Williams LM, Hannah LT, Ross AW, McKelvey WA, Robinson JJ. Oestrogen and progesterone receptor immunoreactivity and c-fos expression in the ovine cervix. Journal of Reproduction and Fertility.1999;115:(2):287-292.
  59. Brannian JD, Zhao Y, McElroy M. Leptin inhibits gonadotrophin-stimulated granulosa cell progesterone production by antagonizing insulin action. Human Reproduction.1999;14:(6):1445-1448.
  60. Zhao Y, Burbach JA, Roby KF, Terranova PF, Brannian JD. Macrophages are the major source of Tumor Necrosis Factor a in the porcine corpus luteum. Biology of Reproduction.1998;59:(6):1385-1391.
  61. Brannian JD, Zhao Y, Burbach JA. Localization of lipid peroxidation-specific epitopes in the corpus luteum. Biology of Reproduction.1997;57:(6):1461-1466.
  62. Zhao Y, Luck MR. Collagen and its remodeling in ruminant follicles/corpora lutea. Advances in Contraceptive Delivery Systems.1996;12:(1-2):41-49.
  63. Luck MR, Silvester LM, Zhao Y. The role of the extracellular matrix in reproductive tissues. Reproduction in Domestic Animals.1996;31:(3):403-405.
  64. Zhao Y, Luck MR. Bovine granulosa cells express extracellular matrix proteins and their regulators during luteinization in culture. Reproduction Fertility and Development.1996;8:(2):259-266.
  65. Luck MR, Zhao Y, Silvester LM. Identification and localization of collagen types I and IV in the ruminant follicle and corpus luteum. J Reprod Fertil Suppl. 1995; 49:517-21.
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  66. Zhao Y, Luck MR. Gene expression and protein distribution of collagen, fibronectin and laminin in bovine follicle and corpus luteum. Journal of Reproduction and Fertility.1995;104:(1):115-123.
  67. Luck MR, Zhao Y. Structural remodeling of reproductive tissues. Journal Endocrinology.1995;146:(2):191-195.
  68. Zhao Y, Luck MR. Ovary: extracellular matrix proteins. Journal Harbin Medical University.1994;28:(3):62-74.
  69. Cheng CP, Ma Q, Gao EW, Wang XN, Zhao Y, Wang Q, Zhang Q, Ni J. The modulating effect of tyrosine on human chorionic gonadotropin-induced progesterone production in the ovary. Journal of Harbin Medical University.1994;28:(3):22-44.
  70. Zhao Y, Shao ZY, Wang JH, Cheng CP. Effects of b-CGRP and a-hANP on corticosterone secretion in rats. Basic Medical Sciences and Clinics.1993;13:(1):34-36.
  71. Zhao Y, Ni J, Wang JH, Cheng CP, Lu GC, Wang D, Wang NG. Effect of amino acids and small peptide on oestrin and progestin secretion of granulosa cells of rats in vitro. Basic Medical Sciences and Clinics.1993;2:40-44.
  72. Luck MR, Zhao Y. Identification and measurement of collagen in the bovine corpus luteum and its relationship with ascorbic acid and tissue development. Journal Reproduction and Fertility .1993;99:(2):647-652.
  73. Zhao Y, Lu GS, Cheng CP. Mechanisms of inhibitory effect of Gly-Tyr-NH2 and Gly-Ser-Lys on progesterone production by corpus luteal cells of rat. Reproduction & Contraception.1992;12:(2):7-10.
  74. Zhao Y, Ni J, Wang XN, Cheng CP, Wang DX, LU GS, Wang NG, Liu W, Guan MZ. Effect of synthetic small peptides on progesterone production by rat corpus luteal cells. Reproduction and Contraception.1992;12:(1):19-23.
  75. Zhao Y. Experimental studies on the action of synthesized small peptides on ovarian steroidogenesis in the rat. Basic Medical Science and Clinics.1991;22:(1):17-19.
  76. Zhao Y, Wang XH, Cheng CP. Effect of calcitonin gene-related peptide on progesterone and estradiol production of rat ovarian cells in vitro. Chinese Science Bulletin.1991;36:(20):1738-1741.
  77. Zhao Y, Wang JH, Cheng CP. Effect of K+, Na+ ionic channel blocker on progesterone production by rat corpus luteal cells. Acta Physiological Sinica.1991;43:(5):508-511.
  78. Zhao Y, Wang JH, Cheng CP. Effect of ANP on oestradiol and progesterone production by rat ovarian cells. Acta Physiological Sinica.1991;43:(6):580-583.
  79. Zhao Y, Wang XN, Cheng CP, Wang DX, Lu QS, Wang NG, Liu W, Guan MZ. Effect of 12 synthesized small peptides on progesterone production by isolated corpus luteal cells of rat. Reproduction and Contraception.1991;3:(1):56-59.
  80. Zhao Y, Wang XH, Cheng CP. Effect of calcitonin gene-related peptide on progesterone and steroidal production in rat ovarian cells. Science Bulletin.1991;36:(7):542-544.
  81. Wang XH, Zhao Y, Cheng CP. Effect of tyrosine, serine, and threonine on the oxytocin induced progesterone production by isolated corpus luteal cells of rats. Journal of Harbin Medical University.1991;25:(2):79-81.
  82. Zhao Y, Cheng CP. Growth factors influence differentiation of granulosa cells. Progress in Physiological Science.1990;21:(2):167-170.
  83. Zhao Y, Cheng CP. Estrogen and progesterone receptors. Basic Medical Science and Clinics.1990;10:(3):1-5.
  84. Ni J, Zhao Y. Regulation of ovarian follicle function. Basic Medical Science and Clinics.1990;10:(6):331-336.
  85. Zhao Y, Wang XN, Cheng CP, Wang DX, Lu QS, Wang NG, Liu W, Guan MZ. Effect of 12 newly synthesized small peptides on ovarian steroidogenesis. Basic Medical Science and Clinics.1990;10:(5):308-309.
  86. Ni J, Zhao Y, Zhang W, Cheng CP. The change of progesterone and tyrosine content in luteal cell suspension of rat at different time of incubation. Journal of Harbin Medical University.1989;23:(2):96-98.
  87. Zhao Y, Gao SZ, Cheng CP. Dynamics of Tyr contents in the ovary of mice at various physiological stages. Reproduction and Contraception.1989;9:(3):55-58.
  88. Zhao Y, Cheng CP. The effect of EGF, epinephrine and PGE2 on progesterone secretion of rat corpus luteal cells in vitro. Physiology Sciences.1989;9:(5):281-284.
  89. Zhao Y, Cheng CP. The effect of amino acids on endocrine function. Journal of Harbin Medical University.1989;23:(6):454-456.
  90. Tang JP, Zhao Y, Huang LP, Cheng CP. The changes of tyrosine content in ovaries of mice. Journal of Harbin Medical University.1986;20:(2):4-6.
  91. Zhao Y, Gao SZ. Changes in contents of aromatic amino acids in ovaries of mice before and after ovulation. Journal of Harbin Medical University.1986;20:(3):7-9.