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Harry H. Yoon, M.D.

  1. Oncologist


  1. Rochester, Minnesota



The research focus of Harry H. Yoon, M.D., is in the development of novel GI malignancies. Dr. Yoon is an internationally recognized expert and clinical investigator in gastroesophageal and other GI cancers. Through his leadership roles, Dr. Yoon helps provide strategic leadership for scientific, practice, and educational activities within the Mayo Clinic Comprehensive Cancer Center, the Department of Oncology in Rochester, MN, and across the three national Mayo Clinic destination sites (Minnesota, Arizona, Florida) and Mayo Clinic Health System. The theme of Dr. Yoon's research career has been to develop genomic/molecularly-informed therapies in GI cancers tailored to an individual's tumor and host environment. He leads an R01-funded clinical/translational research program from the U.S. National Institutes of Health/National Cancer Institute that seeks to enhance cooperativity of immunotherapy with anti-angiogenic and other therapies. He (co)leads multiple investigator-initiated and Industry-sponsored Phase 1-3 clinical trials. He is frequently invited to speak at internationally attended scientific conferences, including those sponsored by the American Society of Clinical Oncology (ASCO) and European Society of Medical Oncology (ESMO) and to serve on global advisory boards of pharmaceutical/biotechnology firms to guide innovation in drug development. He serves on the guidelines panel of the U.S. National Comprehensive Cancer Network (NCCN) for esophageal/gastroesophageal junction and gastric cancer. He has expertise in cancers of the digestive system.

  • Gastrointestinal cancers
  • Esophageal/gastroesophageal junction or gastric cancers
  • Colon cancer
  • Rectal cancer
  • Pancreaticobiliary cancer
  • Small bowel cancer
  1. 2008
    Clinical Post Doctoral Fellowship - Medical OncologyThe Johns Hopkins University School of Medicine
  2. 2006
    MHSGraduate Training Program in Clinical Investigation (GTPCI), Johns Hopkins School of Public Health
  3. 2004
    Internship/Residency - Internal MedicineTraditional Program, Yale-New Haven Hospital, Yale University School of Medicine
  4. 2001
    MDYale University School of Medicine
  5. 1993
    BS - Molecular Biophysics & BiochemistryYale College


  1. 2007
    Medical OncologyAmerican Board of Internal Medicine

Awards and honors

  1. 2011
    Charles F. and Marcia L. Forcey Career Development Award in Esophageal Cancer ResearchMayo Clinic Development Department and Cancer Center
  2. 2010
    Top Educator 2010Internal Medicine Residency Program, Department of Internal Medicine
  3. 2008
    Diagnostic Development Tutorial: From Hypothesis to ProductAACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics, American Association for Cancer Research
  4. 2008
    Paul Calabresi (K12) Clinical Translational Research Career Development ProgramMayo Clinic Cancer Center
  5. 2007
    Young Investigator AwardAmerican Society of Clinical Oncology
  6. 2001
    ACP/ASIM Internal Medicine AwardConnecticut Chapter ACP-ASIM
  7. 1989
    Cum LaudeYale College

Professional memberships

  1. 2022 - present
    Member and ReviewerKL2 Scientific Review Committee
  2. 2022
    Session leaderMayo Clinic GI Disease Groups
  3. 2022
    National Advisory BoardDaiichi Sankyo and AstraZeneca
  4. 2022 - present
    GI Executive Advisory CouncilAmgen Pharmaceuticals
  5. 2022 - present
    Global Steering Committee MemberBeiGene
  6. 2021
    Esophageal Cancer Advisory BoardBeiGene
  7. 2021
    Esophageal Cancer Advisory BoardNovartis Pharmaceuticals
  8. 2021
    Global Gastric Cancer Advisory BoardBristol Myers Squibb
  9. 2021
    National Mock FDA Advisory BoardMerck & Co., Inc.
  10. 2021
    Gastric Cancer Advisory BoardZymeworks
  11. 2021
    National Gastric Cancer Advisory BoardOncXerna
  12. 2020
    Global Gastric Cancer Advisory BoardZymeworks
  13. 2020
    Global Gastric Cancer Advisory BoardMacrogenics
  14. 2019 - present
    Active MemberGI Disease Group Steering Committee
  15. 2019
    MemberAstellas Pharma Inc
  16. 2019
    MemberALX Oncology
  17. 2019
  18. 2019
    Advisory Board MemberMerck Research Laboratories
  19. 2019 - present
    Steering Committee MemberMacrogenics
  20. 2019 - present
    MemberEsophageal and Gastric Cancer Committee, National Comprehensive Cancer Network
  21. 2018 - present
  22. 2018 - present
    Steering Committee MemberMerck Research Laboratories
  23. 2018 - present
    Steering Committee MemberLSK Biopharma
  24. 2017 - present
    ChairGastroesophageal Cancer Disease Group, Mayo Clinic Cancer Center
  25. 2017 - present
    MemberGI Lab Med & Pathol Disease-Oriented Group
  26. 2016 - 2019
    Alliance GI RepresentativeMayo Clinic Cancer Center, Alliance for Clinical Trials in Oncology, Esophagogastric Task Force of the Gastrointestinal Steering Committee
  27. 2015 - 2020
    PanelistNational Comprehensive Cancer Network Occult Primary Guidelines Panel
  28. 2015 - present
    Faculty AdvisorThe Angiogenesis Foundation Center of Excellence
  29. 2014
    Advisory Board MemberLilly Oncology
  30. 2014 - 2017
    MemberGastric-Esophageal Cancer Specialty Council
  31. 2014
    AdvisorFivePrime Gastric Cancer Advisory Board
  32. 2013 - present
    MemberMerrimack MM-111 Translational Science Steering Committee
  33. 2012 - 2014
    MemberAcademic and Community Cancer Research United, Mayo Clinic Cancer Center
  34. 2012
    MemberTask Force - Standardizing clinical management of patients with esophageal cancer
  35. 2011
    Advisory Board MemberGenentech USA
  36. 2011 - present
    MemberAcademic and Community Clinical Research United
  37. 2010 - 2014
    MemberNCI Task Force, National Cancer Institute, National Institutes of Health
  38. 2010
    Advisory Board MemberGenentech USA
  39. 2009 - present
    Ad Hoc ReviewerMayo Clinic Scientific Review Committee
  40. 2008 - present
    MemberAmerican Association for Cancer Research
  41. 2008 - 2014
    MemberGI Cancers DOG, Disease/Discipline Oriented Groups (DOGs), Mayo Clinic Cancer Center
  42. 2008 - 2012
    MemberNorth Central Cancer Treatment Group, NCI Cooperative Group Affiliation, National Cancer Institute
  43. 2008 - present
    MemberEsophageal Adenocarcinoma Barretts Esophagus Consortium
  44. 2008 - present
    MemberMinnesota Medical Association
  45. 2006 - present
    MemberAmerican Society of Clinical Oncology


Research activities

See a description of research activities.