Mayo Clinic's approach

Mayo Clinic experts have experience using IORT to treat many types of cancer, including:

Radiation oncologists at Mayo Clinic believe that IORT is ideal for treating cancers that are likely to come back in the same area after surgery alone. Also, IORT is helpful for cancers that are near sensitive organs.

Your Mayo Clinic care team

At Mayo Clinic, radiation oncologists, medical oncologists, surgeons and pathologists work as a team to provide comprehensive care for those considering IORT. Other professionals are included as needed.

Advanced radiation treatment delivery

Mayo Clinic radiation oncologists can use the latest technology to help with radiation treatment planning and delivery.

Mayo Clinic's campus in Arizona uses a mobile radiation therapy device to deliver IORT in the operating room. Mayo Clinic's campus in Minnesota has a special operating room just for IORT procedures, as well as a mobile radiation therapy device that can be used in other operating rooms.

Expertise and rankings

Mayo Clinic radiation oncologists are widely respected for their expertise in planning and delivering radiation therapy using advanced technology. This expertise and experience ensure that your team is prepared with the knowledge and resources to provide you with exactly the care you need.

Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Jacksonville, Florida, and Mayo Clinic in Phoenix/Scottsdale, Arizona, are ranked among the Best Hospitals for cancer care by U.S. News & World Report. Mayo Clinic Children's Center in Rochester is ranked the No. 1 hospital in Minnesota, and the five-state region of Iowa, Minnesota, North Dakota, South Dakota and Wisconsin, according to U.S. News & World Report's 2023–2024 "Best Children's Hospitals" rankings.

Mayo Clinic Comprehensive Cancer Center meets strict standards for a National Cancer Institute comprehensive cancer center, which recognizes scientific excellence and a multidisciplinary approach to cancer prevention, diagnosis and treatment.

Locations, travel and lodging

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

For more information on visiting Mayo Clinic, choose your location below:

Costs and insurance

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.

In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals, or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Learn more about appointments at Mayo Clinic.

Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.

More information about billing and insurance:

Mayo Clinic in Arizona, Florida and Minnesota

Mayo Clinic Health System

Clinical trials

Explore Mayo Clinic studies of tests and procedures to help prevent, detect, treat or manage conditions.

Jan. 07, 2023
  1. Tepper JE, et al., eds. Intraoperative radiation. In: Gunderson & Tepper's Clinical Radiation Oncology. 5th ed. Elsevier; 2021. Accessed Nov. 16, 2022.
  2. Jethwa KR, et al. The use of intraoperative radiation therapy in the management of locally recurrent rectal cancer. Seminars in Colon and Rectal Surgery. 2020; doi:10.1016/j.scrs.2020.100763.
  3. Mitin T. Radiation therapy techniques in cancer treatment. Accessed Dec. 1, 2022.
  4. Jethwa KR (expert opinion). Mayo Clinic. Dec. 16, 2022.

Intraoperative radiation therapy (IORT)