Craniopharyngioma
    Symptoms and causes

    Overview

    Craniopharyngioma is a rare type of noncancerous brain tumor.

    Craniopharyngioma begins as a growth of cells near the brain's pituitary gland. The pituitary gland makes hormones that control many body functions. As a craniopharyngioma slowly grows, it can affect the pituitary gland and other nearby structures in the brain.

    Craniopharyngioma can happen at any age, but it occurs most often in children and older adults. Symptoms include changes in vision over time, fatigue, headaches and urinating more often. Children with craniopharyngioma may grow slowly and may be smaller than expected.

    Illustration showing the pituitary gland and hypothalamus

    Pituitary gland and hypothalamus

    The pituitary gland and the hypothalamus are in the brain. They make hormones that manage many needed works of the body.

    Symptoms

    Signs and symptoms of craniopharyngioma may include:

    • Headaches.
    • Vision changes.
    • Nausea and vomiting.
    • Increased urination.
    • Sleepiness.
    • Memory troubles.
    • Loss of balance.
    • Trouble walking.
    • Changes in personality or behavior.
    • Weight gain and slowed growth in children.

    When to see a doctor

    Make an appointment with a doctor or other healthcare professional if you have any symptoms that worry you.

    Causes

    It's not clear what causes craniopharyngioma. Craniopharyngioma begins as a growth of cells near the brain's pituitary gland. The pituitary gland makes hormones that control many body functions.

    Craniopharyngioma happens when cells develop changes in their DNA. A cell's DNA holds the instructions that tell the cell what to do. In healthy cells, the DNA gives instructions to grow and multiply at a set rate. The instructions tell the cells to die at a set time. In tumor cells, the DNA changes give different instructions. The changes tell the tumor cells to grow and multiply quickly. Tumor cells can keep living when healthy cells would die. This causes too many cells.

    Risk factors

    Healthcare professionals haven't found many risk factors for craniopharyngioma. This tumor can happen at any age. But it's more common in children and older adults.

    1. Ferri FF. Craniopharyngioma. In: Ferri's Clinical Advisor 2023. Elsevier; 2023. https://www.clinicalkey.com. Accessed April 28, 2023.
    2. Harsh GR, et al. Craniopharyngioma. https://www.uptodate.com/home. Accessed April 28, 2023.
    3. Childhood craniopharyngioma treatment (PDQ) – Patient version. National Cancer Institute. https://www.cancer.gov/types/brain/patient/child-cranio-treatment-pdq. Accessed April 28, 2023.
    4. Winn HR, ed. Pediatric craniopharyngiomas. In: Youmans and Winn Neurological Surgery. 8th ed. Elsevier; 2023. https://www.clinicalkey.com. Accessed April 28, 2023.
    5. Craniopharyngioma. Cancer.Net. https://www.cancer.net/cancer-types/craniopharyngioma-childhood/view-all. Accessed April 28, 2023.

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