Print OverviewFacial fillers are gel-like substances injected into or under the skin to smooth it and make wrinkles less noticeable. Before the facial filler is injected, you're given a numbing medicine. Facial fillers are biodegradable materials that dissolve over time and are absorbed by the body. They're also called soft tissue fillers. The procedure usually isn't suggested for people with bleeding disorders, a weak immune system and certain other conditions. Types of facial fillersFacial fillers for wrinkles that are FDA-approved injectables include: Hyaluronic acid (Restylane, Juvederm, others). This is the most common filler used for wrinkles. Hyaluronic acid is a naturally occurring sugar in the body. The results typically last 6 to 12 months. Calcium hydroxylapatite (Radiesse). This filler is used to contour the jaw line, restore volume in the cheeks, and treat deeper wrinkles and skin folds. Calcium hydroxylapatite is a mineral found in bone. The results last up to a year when used for contouring and three years when used to fill wrinkles. Fat grafting. With this method, fat is removed from your body using liposuction. It is then injected into the cheek, temple, lips or forehead. The effects may last one or two years. Poly-L-lactic acid (Sculptra). This product is used to restore facial volume lost due to aging or illness. Poly-L-lactic acid, also called PLLA, is a manufactured substance that is slowly absorbed by the body. Two or three sessions are usually required. The effects last up to two years. Permanent soft tissue filler (Bellafill). This filler is used to smooth deep wrinkles around the mouth. The body can't absorb this type of filler, so it is permanent. You won't need to be reinjected. Permanent soft tissue filler generally isn't recommended as a first-time facial filler treatment. Facial fillers for wrinkles are safe in all skin colors. They carry very little risk for changes in skin color, also called postinflammatory pigmentation, or keloid scarring. Talk with your healthcare professional about the pros and cons of each type of facial filler.Products & ServicesA Book: Mayo Clinic Family Health BookAssortment of Health Products from Mayo Clinic StoreNewsletter: Mayo Clinic Health Letter — Digital EditionShow more products from Mayo Clinic RisksAs with any procedure, injecting facial filler for wrinkles has risks, including: Swelling. Pain. Bleeding and bruising. Itching. Rash. Infection. Unexpected changes in the surface, contours and firmness of the skin. Accidental injection of the filler into a blood vessel, which can cause stroke, death of tissue or blindness. Allergic reaction. To minimize these risks, seek care from a healthcare professional who understands anatomy, who has done this procedure many times with success and who knows how to treat emergency situations. FDA-approved dermal fillers are available by a prescription for injection by a licensed healthcare professional. What you can expectBefore the facial filler is injected, you're given a numbing medicine. Or sometimes the filler is mixed with a numbing medicine to make the procedure more comfortable. The procedure usually is done in an outpatient setting and takes up to an hour. You may have mild discomfort, bruising and swelling for up to a week. After the swelling goes down, you might need a touch-up injection for best results. How long the effect lasts depends on your skin and the type of filler used. Repeat injections are needed to maintain results. By Mayo Clinic Staff Facial fillers for wrinkles care at Mayo Clinic Request an appointment Doctors & Departments July 15, 2025 Print Show references AskMayoExpert. Soft tissue fillers and other injectables. Mayo Clinic; 2020. Kelly AP, et al., eds. Postinflammatory hyperpigmentation/periorbital hyperpigmentation. In: Taylor and Kelly's Dermatology for Skin of Color. 2nd ed. McGraw Hill; 2016. https://accessmedicine.mhmedical.com. Accessed Dec. 13, 2023. Medical review (expert opinion). Mayo Clinic. May 3, 2023. Dermal filler do's and don'ts for wrinkles, lips and more. U.S. Food and Drug Administration. https://www.fda.gov/consumers/consumer-updates/dermal-filler-dos-and-donts-wrinkles-lips-and-more. Accessed Sept. 20, 2023. Carruthers J, et al., eds. Introduction to temporary fillers: Pros and cons. In: Procedures in Cosmetic Dermatology: Soft Tissue Augmentation. 5th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed Sept. 20, 2023. Desmond Markey J, et al. Advances in nonsurgical periocular rejuvenation. Facial Plastic Surgery Clinics of North America. 2022; doi:org/10.1016/j.fsc.2022.03.006. Health Education & Content Services. Smoothing wrinkles and scars by soft tissue augmentation. Mayo Clinic; 2017. Carruthers J, et al., eds. Complications of temporary fillers. In: Procedures in Cosmetic Dermatology: Soft Tissue Augmentation. 5th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed Dec. 13, 2023. Carruthers J, et al., eds. Bellafill. In: Procedures in Cosmetic Dermatology: Soft Tissue Augmentation. 5th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed Dec. 13, 2023. Carruthers J, et al., eds. Poly-L-lactic acid. In Procedures in Cosmetic Dermatology: Soft Tissue Augmentation. 5th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed Dec. 13, 2023. Fillers: FAQs. American Academy of Dermatology. https://www.aad.org/public/cosmetic/wrinkles/fillers-faqs. Accessed Dec. 13, 2023. Chesnut, C. Restoration of visual loss with retrobulbar hyaluronidase injection after hyaluronic acid filler. Dermatologic Surgery. 2018; doi:10.1097/DSS.0000000000001237. Carruthers J, et al. Injectable soft tissue fillers: Overview of clinical use. https://www.uptodate.com/contents/search. Accessed Dec. 19, 2023. Carruthers J, et al. Injectable soft tissue fillers: Permanent agents. https://www.uptodate.com/contents/search. Accessed Dec. 19, 2023. Related Wrinkles Products & Services A Book: Mayo Clinic Family Health Book Assortment of Health Products from Mayo Clinic Store Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Facial fillers for wrinklesAboutDoctors&DepartmentsCare atMayoClinic Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship Policy Opportunities Ad Choices Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. NEW: Mayo Clinic Guide to Better Sleep Listen to Health Matters Podcast Mayo Clinic on Incontinence The Essential Diabetes Book FREE Mayo Clinic Diet Assessment Mayo Clinic Health Letter - FREE book PRC-20394066 Tests & Procedures Facial fillers for wrinkles