Vagus nerve stimulation (VNS) to treat epilepsy

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Doctors who perform this procedure

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Displaying 1-10 out of 10 doctors available

  1. Rushna P. Ali, M.D.

    Rushna P. Ali, M.D.

    1. Neurosurgeon
    1. Rochester, MN
    Areas of focus:

    Spinal cord stimulation, Radiofrequency ablation, Intrathecal baclofen pump implantation, Deep brain stimulation, Vagus... nerve stimulation, Responsive neurostimulation therapy, Ablation therapy, Computer assisted brain surgery, Dorsal root ganglion stimulator implantation, Intrathecal pump implantation, Dorsal root entry zone lesioning, Occipital nerve stimulation, Microvascular decompression surgery, Stroke, Chronic pain, Epilepsy, Trigeminal neuralgia, Movement disorder, Neuropathic pain syndrome, Cancer-related pain, Neuralgia

  2. Anteneh M. Feyissa, M.D.

    Anteneh M. Feyissa, M.D.

    1. Neurologist
    1. Jacksonville, FL
    Areas of focus:

    EEG, Deep brain stimulation, Vagus nerve stimulation, Responsive neurostimulation therapy, Intraoperative neurophysiolo...gic monitoring, Cortical stimulation mapping, Epilepsy, Seizure , Autoimmune disease, Brain tumor, Autoimmune epilepsy

  3. Anthony L. Fine, M.D.

    Anthony L. Fine, M.D.

    1. Neurologist
    1. Rochester, MN
    Areas of focus:

    EEG, Subdural electrode monitoring, Vagus nerve stimulation, Video EEG monitoring, Epilepsy, Seizure , Febrile seizure,... Absence seizure, Tonic-clonic seizure, Temporal lobe seizure

  4. Brin E. Freund, M.D.

    Brin E. Freund, M.D.

    1. Neurologist
    1. Jacksonville, FL
    Areas of focus:

    EEG, Subdural electrode monitoring, Deep brain stimulation, Vagus nerve stimulation, Responsive neurostimulation therap...y, Intraoperative neurophysiologic monitoring, Stereoelectroencephalography, Electrocorticography, Epilepsy, Seizure , Autoimmune epilepsy, Brain tumor-associated epilepsy

  5. Nick M. Gregg, M.D.

    Nick M. Gregg, M.D.

    1. Neurologist
    1. Rochester, MN
    Areas of focus:

    EEG, Deep brain stimulation, Vagus nerve stimulation, Responsive neurostimulation therapy, Epilepsy

  6. Seyed M. Mirsattari, M.D., Ph.D.

    Seyed M. Mirsattari, M.D., Ph.D.

    1. Neurologist
    1. Jacksonville, FL
    Areas of focus:

    Neurostimulation treatment, EEG, Lumbar puncture, Deep brain stimulation, Vagus nerve stimulation, Intraoperative neuro...physiologic monitoring, Stereoelectroencephalography, Functional MRI , Electrocorticography, Epilepsy, Seizure , Functional neurologic disorder, Psychogenic nonepileptic seizure, Autoimmune epilepsy

  7. Gloria I. Ortiz Guerrero, M.D.

    Gloria I. Ortiz Guerrero, M.D.

    1. Neurologist
    1. Rochester, MN
    Areas of focus:

    EEG, Deep brain stimulation, Vagus nerve stimulation, Responsive neurostimulation therapy, Neuromodulation therapy, Epi...lepsy

  8. Jonathon J. Parker, M.D., Ph.D.

    Jonathon J. Parker, M.D., Ph.D.

    1. Neurosurgeon
    1. Phoenix, AZ
    Areas of focus:

    Epilepsy monitoring, Deep brain stimulation, Vagus nerve stimulation, Craniotomy, Epilepsy surgery, Brain mapping, Awak...e brain surgery, Stereoelectroencephalography, Brain tumor surgery, Intraoperative magnetic resonance imaging, Brain biopsy, Temporal lobectomy, Dorsal root entry zone lesioning, Asleep deep brain stimulation, Robotic SEEG, Epileptic focus disconnection surgery, Stereotactic laser temporal lobectomy, Stereotactic laser ablation, MRI-guided laser ablation, Intraoperative electrocorticography, MRI-guided deep brain stimulation, Robotic depth electrode monitoring, Corpus callosotomy, Pterional craniotomy, Epilepsy, Parkinson's disease, Essential tremor, Obsessive compulsive disorder, Tourette syndrome, Dystonia, Glioblastoma, Glioma, Thalamic pain, Glioma-associated epilepsy, Low grade glioma of brain, Facial pain disorder, Focal cortical dysplasia, Mesial temporal sclerosis, Anesthesia dolorosa, Hypothalamic hamartoma, Central pain syndrome, Gray matter heterotopia, Brachial plexus avulsion pain, Primary dystonia, DYT1 dystonia, Secondary dystonia

  9. Lily C. Wong-Kisiel, M.D.

    Lily C. Wong-Kisiel, M.D.

    1. Neurologist
    1. Rochester, MN
    Areas of focus:

    EEG, Subdural electrode monitoring, Vagus nerve stimulation, Video EEG monitoring, Epilepsy, Seizure , Febrile seizure,... Angelman syndrome, Absence seizure, Autoimmune epilepsy, Tonic-clonic seizure, Frontal lobe seizure

  10. Richard S. Zimmerman, M.D.

    Richard S. Zimmerman, M.D.

    1. Neurosurgeon
    1. Phoenix, AZ
    Areas of focus:

    Vagus nerve stimulation, Craniotomy, Epilepsy surgery, Ablation therapy, Carotid endarterectomy, Brain tumor surgery, B...rain biopsy, Hemifacial spasm surgery, Trigeminal neuralgia surgery, Aneurysm surgery, Arteriovenous malformation surgery, Pterional craniotomy, Epilepsy, Trigeminal neuralgia, Meningioma, Acoustic neuroma, Chordoma, Brain tumor, Brain metastasis, Glioblastoma, Astrocytoma, Oligodendroglioma, Aneurysm, Neurofibromatosis, Glioma, Ependymoma, Arteriovenous malformation, Plexiform neurofibroma, Ganglioglioma, Neurofibroma, Hemifacial spasm, Choroid plexus papilloma, Benign brain tumor

Research

Mayo Clinic researchers study epilepsy treatments, including neuromodulation and brain stimulation for drug-resistant epilepsy. Research includes ways to improve seizure control, guide treatment with EEG and MEG biomarkers, optimize stimulation and understand which treatments may work best for different people.

A major area of investigation is pairing VNS with rehabilitation following ischemic stroke, including studies of upper-limb recovery, gait and mobility, cognition, functional brain connectivity, and real-world outcomes with the Vivistim System. Mayo's broader VNS research has extended into metabolic, neurological and behavioral applications. These include epilepsy, glucose metabolism, migraine, post-COVID fatigue, chronic dizziness and smoking cessation. Previous research has evaluated vagal stimulation in the heart.

Neurology - Epilepsy Research

Brain Adaptation and Stimulation Laboratory

Publications

See a list of publications about vagus nerve stimulation by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

Research Profiles

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By Mayo Clinic Staff
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About
Oct. 30, 2026
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  1. Abdennadher M, et al. Vagus nerve stimulation therapy in epilepsy: an overview of technical and surgical method, patient selection, and treatment outcomes. Brain Sciences. 2024; doi:10.3390/brainsci14070675.
  2. Muniyandi M, et al. Significant reduction of seizure frequency in patients with drug-resistant epilepsy by vagus nerve stimulation: systematic review and meta-analysis. Epilepsy Research. 2025; doi:10.1016/j.eplepsyres.2025.107510.
  3. Clifford HJ, et al. Vagus nerve stimulation for epilepsy: a narrative review of factors predictive of response. Epilepsia. 2024; doi:10.1111/epi.18153.
  4. Haneef Z, et al. Neurostimulation in generalized epilepsy: a systematic review and meta-analysis. Epilepsia. 2023; doi:10.1111/epi.17524.
  5. Shi J, et al. Comparative efficacy of neuromodulatory strategies for drug-resistant epilepsy: a systematic review and meta-analysis. World Neurosurgery. 2025; doi:10.1016/j.wneu.2024.09.084.
  6. Yang VB, et al. Characterizing the safety profile of vagus nerve stimulation devices for epilepsy from 21,448 manufacturer and user reports. Journal of Neurosurgery. 2024; doi:10.3171/2024.3.JNS231942.
  7. Melese DM, et al. The effect of vagus nerve stimulation (VNS) on seizure control, cognitive function, and quality of life in individuals with drug-resistant epilepsy: a systematic review article. Epilepsia Open. 2024; doi:10.1002/epi4.13066.
  8. Medical review (expert opinion). Mayo Clinic. Oct. 25, 2026.

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Vagus nerve stimulation (VNS) to treat epilepsy