Ketamine intervention and treatment-resistant depression June 30, 2014 Overview Show transcript Overview Many people with depression do not respond effectively to first line antidepressant treatments. It usually takes at least three weeks from the time treatment begins for those who do respond to see any clinical benefit. Mayo Clinic is eager to develop promising new ways to diagnose and treat treatment-resistant depression. Susannah J. Tye, Ph.D., with Psychiatry and Psychology at Mayo Clinic's campus in Rochester, Minnesota, discusses research to optimize treatment with ketamine intervention for people with treatment-resistant depression. Related ContentArticleKetamine research focuses on mechanisms of action and biomarker developmentArticleKetamine: Exploring continuation-phase treatment for depression VID-20433351 Medical Professionals Ketamine Intervention and Treatment-Resistant Depression