Pediatrics

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Early Naturalistic Hands-on Autism Caregiver Training

   Rochester, Minn.

   The purpose of this study is to pilot test the ENHANCE intervention to evaluate methodology, feasibility based on caregiver input, and preliminary caregiver satisfaction. The primary outcomes will be feedback from parents, participant completion/atrition rates, the interventionist study log, and interventionist/caregiver/fidelity. Second, we aim to examine preliminary impact of the naturalistic intervention on child social communication and repetitive behavior in order to estimate clinically meaningful change for future research studies. 

2. AVTX-803 in Patients with Leukocyte Adhesion Deficiency Type II

   Rochester, Minn.

   The purpose of this study is to assess the long-term safety and effectiveness of AVTX-803 in subjects with leukocyte adhesion deficiency Type II (LAD II).  

3. Artisan Aphakia Lens for the Correction of Aphakia in Children

   Rochester, Minn.

   To determine the effectiveness of the ARTISAN Aphakia lens in the treatment of aphakia and to precisely define the associated risks and, if possible, identify particular groups of patients who may be at high risk of developing complications resulting from the surgical procedure of implanting an ARTISAN Aphakia lens.

4. Validation of Pediatric Inflammatory Bowel Disease Knowledge Questions (Emma)

   Rochester, Minn., Scottsdale/Phoenix, Ariz.

   The aim of this study is to test the validity of the current question database in a large cohort of children with Inflammatory Bowel Disease (IBD) in several pediatric gastroenterology centers. 

5. A Study of Multicenter Outcomes in Pediatric Status Epilepticus

   Rochester, Minn.

   The purpose of this study is to develop a prospective status epilepticus registry among twelve tertiary care pediatric hospitals in the United States focused on standardizing status epilepticus outcome assessments.

6. Testicular Tissue Cryopreservation in Children

   Rochester, Minn.

   This protocol is being designed to offer testicular tissue cryopreservation to male pediatric patients (0-17 years of age) with fertility threatening medical diagnoses or facing surgery, chemotherapy or radiation therapy that may cause loss of reproductive potential.

7. Innovative Trial for Understanding the Impact of Targeted Therapies in NF2

   Rochester, Minn.

   The purpose of this study is to test multiple experimental therapies simultaneously in patients with neurofibromatosis type 2 (NF2) with associated progressive tumors of vestibular schwannomas (VS), non-vestibular schwannomas (non-VS), meningiomas, and ependymomas. This Master Study is being conducted as a "basket" study that may allow people with multiple tumor types associated with NF2 to receive new drugs throughout this study. Embedded within the Master Study are individual drug substudies. - Investigational Drug Sub-study A: Brigatinib.

8. A Study to Develop Liquid Biopsy for Pediatric Brain Tumor Patients

   Rochester, Minn.

   The purpose of this study is to confirm detection of the H3K27M mutation in patient biofluids (CSF, blood, urine, saliva) and uncover the molecular histone (alkaline protein) profile of H3K trimethylation and H3S phosphorylation in the circulating nucleosomes isolated from the biofluids of patients with H3K27M tumors.

9. A Study to Form a Database of Children with Kidney Stone Disease

   Rochester, Minn.

   The purpose of this study is to establish a database to collect and analyze information on metabolic and environmental risk factors for kidney stone formation in children.

10. A Registry to Follow Long-Term Outcomes for Mother and Child Pairs After Fetal Surgery for Spina Bifida

    Rochester, Minn.

    The purpose of this study is to form a registry of data on the long term physical and mental health outcomes of the mother and child following fetal surgical repair for spina bifida.