Ophthalmology

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study of Video-Oculography to Noninvasively Record Eye Movements in Patients with Strabismus and Nystagmus.

   Rochester, Minn.

   The purpose of this study is to evaluate changes in torsional eye position that accompany strabismus and nystagmus.  These changes, which cannot be visualized on clinical examination, will provide new information about the neurophysiology of these ocular motor disturbances. 

2. Glasses for Adolescent Delayed Sleep-Wake Phase Disorder (GLAD)

   Rochester, Minn.

   The purpose of this study is to determine if evening amber glasses combined with stable wake times will show an increase in total sleep time (TST), and an advance in sleep onset times (shift earlier) compared to the control group.

3. A Study to Compare ADalimumab vs. Conventional ImmunoSupprEssion for Uveitis

   Rochester, Minn.

   The primary purpose of this study is to compare the relative effectiveness of adalimumab vs. conventional immunosuppression at controlling ocular inflammation while permitting tapering of prednisone to < 7.5 mg/day.

4. A Study to Evaluate Variations in Episcleral Venous Pressure

   Rochester, Minn.

   The purpose of this study is to investigate the daily variations in episcleral venous pressure (EVP), the relationship between EVP and blood pressure (BP) variations, and the effect of anti-hypertension medications on these variations. The effect of blood volume increase after water drinking on BP, intraocular pressure (IOP), and EVP will also be assessed.

5. Glaucoma Outcomes Survey

   La Crosse, Wis.

   The purpose of this research study is to determine how useful a questionnaire, the Glaucoma Outcomes Survey (GOS), is as a tool for measuring patient quality of life after undergoing minimally invasive glaucoma surgery combined with cataract surgery.

    

6. A Study to Evaluate the Use of Micropulse Trans-Scleral Cyclophotocoagulation Laser (MP-TSCPC) for Glaucoma Patients

   Jacksonville, Fla.

   The purpose of this study is to evaluate the clinical outcomes of the Micropulse Trans-Scleral Cyclophotocoagulation Laser (MPTSCPC) after 1 day, 1 week,1 month, 3 months, 6 months and one year of follow-up. Its primary objective is to conduct a prospective observational study on the efficacy of using MP-TSCPC to treat glaucoma patients.

7. Artisan Aphakia Lens for the Correction of Aphakia in Children

   Rochester, Minn.

   The purpose of this study is to determine the safety and effectiveness of the Artisan Aphakia Lens in the treatment of aphakia in children.

8. A Study to Determine if the Fluid that Collects in the Retina (Macular Edema) Changes Throughout the Course of a Single Day

   Rochester, Minn.

   The purpose of this study is to determine if the fluid that collects in your retina, known as macular edema, changes throughout the course of a single day. If it does, this may change how the disease is treated in the future.

9. Collaborative Study on Optic Neuritis and Autoantibodies Affecting the Eye

   Rochester, Minn.

   The study proposes to form a consortium of autoimmunity of the optic nerve with the goal of improving diagnosis and treatment of these conditions. 

10. A Natural History Observation and Registry Study of Macular Telangiectasia Type 2: The MacTel Study

    Rochester, Minn.

    The purpose of this study is to develop a Registry of participants with MacTel Type 2 (as confirmed by the Reading Center) who may agree to be contacted for inclusion in future clinical trials. The Registry participants include new participants and participants from the NHO, Genetic I and Genetics II studies who agree to continue to participate. 

    The second objective is to continue to identify whether there is a genetic link associated with MacTel Type 2. All participants who have not previously provided a blood sample will be given the option to provide a blood sample for genetic sequencing.