Description and Brand Names

Drug information provided by: IBM Micromedex

US Brand Name

  1. Vonvendi

Descriptions


Von Willebrand factor recombinant injection is used to treat and control serious bleeding episodes in patients with a bleeding problem called von Willebrand disease (VWD). Von Willebrand factor is normally produced in the body and it helps you form blood clots. Patients with von Willebrand disease do not make enough of this substance to prevent bleeding, so this product is given to increase the blood levels.

Von Willebrand factor recombinant injection is also used to manage bleeding before surgery in patients with von Willebrand disease.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Powder for Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of von Willebrand factor recombinant injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies have not been performed on the relationship of age to the effects of von Willebrand factor recombinant injection in geriatric patients.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood clots, history of or
  • Disseminated intravascular coagulation (DIC, blood clots all over the body), history of or
  • Heart attack, recent or
  • Pulmonary embolism (blood clot in lungs), history of or
  • Stroke, history of—Use with caution. May make these conditions worse.

Proper Use

A nurse or other trained health professional will give you this medicine in a hospital or clinic. It is given through a needle placed into one of your veins.

This medicine may also be given at home to patients who do not need to be in a hospital or clinic. If you are using this medicine at home, your doctor or nurse will teach you how to prepare and inject the medicine. Make sure you understand all of the instructions before giving yourself an injection.

Your dose may change based on where you are bleeding. Do not use more medicine or use it more often than your doctor tells you to.

Precautions

It is very important that your doctor check your progress closely while you are receiving this medicine to make sure it is working properly. Blood tests are needed to check for unwanted effects.

This medicine may increase your chance of having blood clots. Tell your doctor right away if you have a sudden or severe headache, problems with vision or speech, chest pain, or numbness or weakness with this medicine.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you get the injection.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

  1. Chest discomfort
  2. fast, pounding, or irregular heartbeat or pulse

Incidence not known

  1. Blurred vision
  2. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  3. confusion
  4. cough
  5. coughing or spitting up blood
  6. difficulty with swallowing
  7. discoloration of the skin
  8. dizziness
  9. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  10. fainting
  11. hives or welts, itching, or skin rash
  12. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  13. nausea
  14. pain
  15. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  16. redness of the skin
  17. restlessness
  18. sweating
  19. swelling
  20. tightness in the chest
  21. trouble breathing
  22. unusual drowsiness, dullness, tiredness, weakness or feeling of sluggishness
  23. vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  1. Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feeling at the infusion site
  2. change in taste
  3. feeling of warmth
  4. loss of taste
  5. redness of the face, neck, arms, and occasionally, upper chest
  6. shakiness in the legs, arms, hands, or feet
  7. sudden sweating
  8. trembling or shaking of the hands or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.