Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Black, tarry stools
  2. bleeding gums
  3. bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  4. blood in the urine or stools
  5. bluish color of the skin
  6. burning, numbness, tingling, or painful sensations
  7. changes in skin color
  8. chest pain
  9. chills
  10. clay-colored stools
  11. constipation
  12. cough
  13. dark urine
  14. decreased appetite
  15. dizziness
  16. feeling of fullness in the ears
  17. fever
  18. headache
  19. hoarseness
  20. itching, skin rash
  21. loss of appetite
  22. loss of balance
  23. loss of hearing
  24. lower back or side pain
  25. muscle pains, cramps, or stiffness
  26. nausea
  27. painful or difficult urination
  28. pale skin
  29. pinpoint red spots on the skin
  30. ringing or buzzing in the ears
  31. sneezing
  32. sore throat
  33. sores, ulcers, or white spots on the lips or in the mouth
  34. stomach pain or tenderness
  35. swelling of the feet or lower legs
  36. swollen glands
  37. tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
  38. trouble in hearing
  39. troubled breathing with exertion
  40. unsteadiness or awkwardness
  41. unusual bleeding or bruising
  42. unusual tiredness or weakness
  43. yellow eyes or skin

Less common

  1. Chest tightness
  2. increased sensitivity to pain or touch
  3. overactive reflexes, followed by underactive reflexes
  4. trouble breathing

Rare

  1. Agitation
  2. chest discomfort
  3. confusion
  4. decreased awareness or responsiveness
  5. decreased urine output
  6. depression
  7. frequent urination
  8. hostility
  9. irritability
  10. loss of consciousness
  11. lower abdominal cramping
  12. muscle twitching
  13. pain or discomfort in the arms, jaw, back, or neck
  14. rapid weight gain
  15. seizures
  16. severe sleepiness
  17. swelling of the face, ankles, or hands
  18. unusual drowsiness, dullness, or feeling of sluggishness
  19. vomiting

Incidence not known

  1. Anxiety
  2. blistering or sloughing of the skin
  3. bloating
  4. blurred vision
  5. change in walking and balance
  6. clumsiness or unsteadiness
  7. coughing that sometimes produces a pink frothy sputum
  8. difficult, fast, noisy breathing
  9. difficulty in swallowing
  10. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  11. fainting
  12. fast, pounding, or irregular heartbeat or pulse
  13. heartburn
  14. hives or welts
  15. increased sweating
  16. increased thirst
  17. indigestion
  18. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  19. lightheadedness
  20. nervousness
  21. pain or burning in the throat
  22. pain, redness, or swelling in the arm or leg
  23. pains in the stomach, side, or abdomen, possibly radiating to the back
  24. pale skin
  25. pounding in the ears
  26. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  27. redness, swelling, or pain of the skin
  28. scaling of the skin on the hands and feet
  29. slow heartbeat
  30. ulceration of the skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Chest pain
  2. chills
  3. confusion
  4. fainting
  5. fast heartbeat
  6. fever
  7. lightheadedness
  8. lower back or side pain
  9. painful or difficult urination
  10. partial or slight paralysis
  11. rapid, shallow breathing
  12. severe constipation
  13. severe stomach pain
  14. severe vomiting
  15. sores, ulcers, or white spots on the lips or in the mouth
  16. swollen glands
  17. unusual bleeding or bruising
  18. unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Change in taste
  2. diarrhea
  3. difficulty in moving
  4. impaired hearing
  5. joint pain or swelling
  6. lack or loss of strength
  7. thinning or loss of hair

Incidence not known

  1. Back pain
  2. cracked, dry, scaly skin
  3. feeling of warmth or heat
  4. flushing or redness of the skin, especially on the face and neck
  5. jaw pain
  6. pain and redness of the skin at the place of earlier radiation treatment

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.