Proper Use

Drug information provided by: IBM Micromedex

Take this medicine only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine should come with a patient instruction leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Take Xuriden™ with food. You may take Vistogard® without regard to meals.

It is important to take all doses of Vistogard®, even if you feel well.

To prepare:

  • Measure the dose by using either a scale accurate to at least 0.1 gram, or a graduated teaspoon, accurate to the fraction of the dose to be given.
  • Throw away any unused granules left in the packet.

To mix Xuriden™ or Vistogard® with food:

  • Mix the measured amount of granules in 3 to 4 ounces of applesauce, pudding, or yogurt in a small, clean container.
  • Swallow the mixture immediately and do not chew the granules. Do not save any of the mixture to use later.
  • Drink at least 4 ounces of water.

You may also mix Xuriden™ with milk or infant formula:

  • Pour 5 mL of milk or infant formula into a medicine cup.
  • Use an oral syringe to draw up the 5 mL of milk or infant formula.
  • Cap the tip of the syringe, remove the plunger, and pour the measured amount of granules into the syringe.
  • Gently swirl the syringe to mix the granules with the liquid.
  • Place the tip of the syringe in the patient's mouth between the cheek and gum at the back of the mouth. Gently push the plunger all the way down.
  • Refill the syringe with another 5 mL of milk or infant formula.
  • Gently swirl to rinse any remaining granules and flush it to the patient's mouth.
  • This may be followed by a bottle of milk or infant formula, if desired.

If you are taking Vistogard® through a nasogastric tube or gastrostomy tube:

  • Mix 100 mL of food starch-based thickening product in water and stir until the thickener has dissolved.
  • Crush the contents of 1 full 10 gram packet of granules into a fine powder.
  • Add the crushed Vistogard® granules to 100 mL of the thickener mixture. For children receiving less than 10 grams, prepare the mixture at a ratio of no greater than 1 gram per 10 mL of the mixture.
  • Take this medicine through a nasogastric tube or gastrostomy tube.
  • Flush the tube with water.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (oral granules):
    • For treatment of hereditary orotic aciduria:
      • Adults and children—Dose is based on body weight and must be determined by your doctor. The starting dose is 60 milligrams (mg) per kilogram (kg) of body weight (1 to 3 packets) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 120 mg per kg of body weight (2 to 4 packets) once a day.
    • For emergency treatment of patients who have an overdose of fluorouracil or capecitabine:
      • Adults—10 grams (1 packet) every 6 hours for 20 doses.
      • Children—Dose is based on body size and must be determined by your doctor. The starting dose is 6.2 grams per square meter (m[2]) of body size (not to exceed 10 grams per dose) every 6 hours for 20 doses.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you vomit within 2 hours of taking a dose of Vistogard®, take another dose immediately. Then, take your next dose at your regularly scheduled time.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.