Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:


  1. Burning, itching, and redness of the skin
  2. chest pain or tightness
  3. cough
  4. difficulty with swallowing
  5. dizziness
  6. fast heartbeat
  7. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  8. seizures
  9. skin rash, hives, or itching skin
  10. trouble breathing
  11. unusual tiredness or weakness
  12. vomiting

Incidence not known

  1. Agitation
  2. anxiety
  3. bigger, dilated, or enlarged pupils
  4. blistering, peeling, or loosening of the skin
  5. blurred vision
  6. chills
  7. cold sweats
  8. coma
  9. confusion
  10. confusion as to time, place, or person
  11. constricted, pinpoint, or small pupils
  12. cool, pale skin
  13. darkening of the skin
  14. decreased urine output
  15. depression
  16. diarrhea
  17. fainting
  18. fever
  19. hallucinations
  20. headache
  21. holding false beliefs that cannot be changed by fact
  22. increased hunger
  23. increased sensitivity of the eyes to light
  24. increased thirst
  25. irregular or slow heart rate
  26. joint or muscle pain
  27. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  28. loss of appetite
  29. muscle cramps
  30. nausea
  31. nervousness
  32. nightmares
  33. noisy breathing
  34. overactive reflexes
  35. poor coordination
  36. red skin lesions, often with a purple center
  37. red, irritated eyes
  38. shakiness
  39. shivering
  40. slurred speech
  41. sore throat
  42. sores, ulcers, or white spots in the mouth or on the lips
  43. sweating
  44. swelling of the face, ankles, or hands
  45. talking or acting with excitement you cannot control
  46. trembling or shaking
  47. twitching
  48. unusual excitement, nervousness, or restlessness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Black, tarry stools
  2. dark urine
  3. depression
  4. disorientation
  5. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  6. drowsiness to profound coma
  7. fever
  8. headache
  9. irregular, fast or slow, or shallow breathing
  10. lightheadedness
  11. loss of appetite
  12. mood or other mental changes
  13. nausea
  14. pale or blue lips, fingernails, or skin
  15. seeing, hearing, or feeling things that are not there
  16. stomach pain
  17. trouble sleeping
  18. unpleasant breath odor
  19. unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  20. vomiting of blood
  21. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  1. Anxiety
  2. belching
  3. bloated or feeling of fullness
  4. constipation
  5. dry mouth
  6. excess air or gas in the stomach or bowels
  7. false or unusual sense of well-being
  8. feeling of warmth
  9. heartburn
  10. increase in bowel movements
  11. increased sweating
  12. indigestion
  13. loose stools
  14. loss of strength or energy
  15. muscle weakness
  16. numbness or tingling of the hands, legs, and feet
  17. painful or difficult urination
  18. redness of the face, neck, arms, and occasionally the upper chest
  19. sleepiness or unusual drowsiness
  20. soft stools
  21. stomach discomfort
  22. weight loss


  1. Abnormal thinking
  2. blurred vision
  3. change in vision
  4. clumsiness, unsteadiness, trembling, or problems with muscle control or coordination
  5. cold sweats
  6. continuing ringing, buzzing, or unexplained noise in the ears
  7. crying
  8. decrease in the frequency or amount of urination
  9. decreased awareness or responsiveness
  10. decreased interest in sexual intercourse
  11. delusions of persecution, mistrust, suspiciousness, or combativeness
  12. difficulty in passing urine (dribbling)
  13. false or unusual sense of well-being
  14. feeling of constant movement of self or surroundings
  15. feeling unusually cold
  16. headache, severe or continuing
  17. increased muscle tone
  18. involuntary muscle contractions
  19. loss of memory
  20. loss of sense of reality
  21. loss of sexual ability, desire, drive, or performance
  22. migraine headache
  23. morbid dreaming
  24. pounding in the ears
  25. problems with memory
  26. quick to react or overreact emotionally
  27. rapidly changing moods
  28. sensation of spinning
  29. severe stomach pain
  30. shakiness and unsteady walk
  31. shivering
  32. vomiting of blood or material that looks like coffee grounds

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

From Mayo Clinic to your inbox

Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Click here for an email preview.

To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. If you are a Mayo Clinic patient, this could include protected health information. If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail.