Rifampin, Isoniazid, And Pyrazinamide (Oral Route)

Side Effects

Drug information provided by: Merative, Micromedex®

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

1. Chest pain or tightness
2. clumsiness or unsteadiness
3. coughing or spitting up blood
4. dark urine
5. fast, irregular, pounding, or racing heartbeat or pulse
6. loss of appetite
7. nausea
8. numbness, tingling, burning, or pain in the hands and feet
9. pain in the large and small joints
10. sneezing
11. trouble breathing
12. unusual tiredness or weakness
13. vomiting
14. yellow eyes or skin

Less common

1. Chills
2. difficulty in breathing
3. dizziness
4. fever
5. headache
6. hearing loss
7. muscle and bone pain
8. ringing or buzzing or other unexplained noise in the ears
9. shivering
10. skin rash, itching, or redness

Rare

1. Agitation
2. bleeding gums
3. blistering, peeling, or loosening of the skin
4. blood in the urine or stools
5. blurred vision or loss of vision, with or without eye pain
6. bruising
7. confusion
8. darkening of the skin
9. difficulty in swallowing
10. fainting
11. feeling that others are watching you or controlling your behavior
12. feeling that others can hear your thoughts
13. feeling, seeing, or hearing things that are not there
14. fever with or without chills
15. general feeling of tiredness or weakness
16. heavier menstrual periods
17. hives
18. hoarseness
19. hostility
20. increased blood pressure
21. increased thirst
22. irritability
23. light-colored stools
24. lower back or side pain
25. mental depression
26. muscle tenderness, wasting, or weakness
27. persistent bleeding or oozing from puncture sites, mouth, or nose
28. pinpoint red spots on the skin
29. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
30. seizures
31. severe mood or mental changes
32. swelling of the face, ankles, fingers, hands, or lower legs
33. unusual behavior
34. unusual drowsiness, dullness, or feeling of sluggishness
35. weight gain

Incidence not known

1. Ankle, knee, or great toe pain
2. back pain
3. being forgetful
4. black, tarry stools
5. bleeding under the skin
6. blemishes on the skin
7. bloating
8. bloody, severe, or watery diarrhea
9. blue-yellow color blindness
10. bone pain
11. burning while urinating
12. cloudy urine
13. cold, clammy skin
14. constipation
15. cough
16. difficulty seeing at night
17. difficulty with speaking
18. double vision
19. dry mouth
20. fast, weak pulse
21. flushed, dry skin
22. fruit-like breath odor
23. general feeling of discomfort or illness
24. greatly decreased frequency of urination or amount of urine
25. hair loss
26. inability to move the arms, legs, or facial muscles
27. inability to speak
28. increased hunger
29. increased menstrual flow or vaginal bleeding
30. increased sensitivity of the eyes to sunlight
31. increased urination
32. indigestion
33. joint pain, stiffness, or swelling
34. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
35. lightheadedness
36. muscle aches, pains, and tremors
37. night sweats
38. nosebleeds
39. painful or difficult urination
40. pains in the stomach, side, or abdomen, possibly radiating to the back
41. pale skin
42. paralysis
43. pimple
44. prolonged bleeding from cuts
45. rapid, deep breathing
46. red or dark brown urine
47. red skin lesions, often with a purple center
48. red, irritated eyes
49. restlessness
50. runny nose
51. slow speech
52. sore throat
53. sores, ulcers, or white spots on the lips or in the mouth
54. stiff neck
55. stomach cramps or pain
56. sweating
57. swollen glands
58. trouble sleeping
59. unpleasant breath odor
60. unusual bleeding or bruising
61. unusual weight loss

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

1. Blurred vision
2. confusion
3. decreased awareness or responsiveness
4. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
5. fainting
6. fast, pounding, or irregular heartbeat or pulse
7. feeling of fullness in the upper abdomen or stomach
8. loss of consciousness
9. low blood pressure or slow pulse
10. pain in the upper abdomen or stomach
11. reddish-orange to reddish-brown color of the urine, stool, saliva, sputum, sweat, and tears
12. seeing, hearing, or feeling things that are not there
13. seizures
14. severe sleepiness
15. slurring of speech
16. swelling around the eyes and face
17. unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
18. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

1. Sore mouth or tongue

Incidence not known

1. Belching
2. bloated or full feeling
3. excess air or gas in the stomach or bowels
4. not able to concentrate
5. pain or discomfort in the chest, upper stomach, or throat
6. swelling of the breasts or breast soreness in both females and males
7. tooth discoloration

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

• Precautions

Portions of this document last updated: April 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.