Description and Brand Names

Drug information provided by: IBM Micromedex

US Brand Name

  1. Cyramza


Ramucirumab injection is used alone or together with paclitaxel to treat advanced stomach or gastroesophageal junction cancer (cancer that has already spread) after a patient has received other cancer medicines.

Ramucirumab injection is also used in combination with docetaxel to treat metastatic non-small cell lung cancer (cancer that has already spread) in patients who have received other cancer medicines.

Ramucirumab injection is also used in combination with folinic acid, 5-fluorouracil, and irinotecan (FOLFIRI) to treat metastatic colorectal cancer (cancer that has already spread) in patients who have received other cancer medicines.

Ramucirumab injection is also used to treat a type of liver cancer called hepatocellular carcinoma (HCC) in patients who have received other medicines (eg, sorafenib).

This medicine is to be given only by or under the direct supervision of your doctor.

This product is available in the following dosage forms:

  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of ramucirumab injection in the pediatric population. Safety and efficacy have not been established.


Although appropriate studies on the relationship of age to the effects of ramucirumab injection have not been performed in the geriatric population, no geriatric-specific problems have been documented to date.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Tofacitinib

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood clotting problems or
  • Heart attack, recent or
  • Hypertension (high blood pressure) or
  • Kidney disease or
  • Liver disease (eg, cirrhosis) or
  • Stroke, recent or
  • Thyroid problems—Use with caution. May make these conditions worse.

Proper Use

Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

A nurse or other trained health professional will give you this medicine in a medical facility. It is given through a needle placed into one of your veins.

This medicine must be given slowly, so the needle will have remain in place for at least 60 minutes.

You may also receive other medicines (eg, allergy medicine, fever medicine, steroids) to help prevent allergic reactions to the injection.


It is very important that your doctor check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.

Receiving this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment and for 3 months after the last dose. If you think you have become pregnant while receiving the medicine, tell your doctor right away.

This medicine may increase your risk of bleeding and cause delay in wound healing. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers. Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.

You may also need to monitor your blood pressure at home during treatment with ramucirumab. If you notice any changes to your normal blood pressure, call your doctor right away.

This medicine may cause infusion-related reactions, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you have a cough, difficulty with swallowing, dizziness, a fast heartbeat, trouble breathing, chest tightness, swelling in your face or hands, a fever, chills, itching or hives, or lightheadedness while you are receiving this medicine.

This medicine may increase your risk of gastrointestinal perforation (a hole in the stomach with bleeding). Tell your doctor right away if you have severe stomach pain or cramps, bloody, black, or tarry stools, or vomiting of material that looks like coffee grounds.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop receiving this medicine 28 days before and for at least 14 days after having surgery.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine may increase your chance of having a brain condition called reversible posterior leukoencephalopathy syndrome (RPLS). Tell your doctor right away if you develop sudden and severe headaches, fainting spells, seizures, unusual drowsiness, confusion, or problems with vision, speech, or walking.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, troubled breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

Talk with your doctor before receiving this medicine if you plan to have children. Some women who use this medicine have become infertile (unable to have children).

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Back pain or spasms
  2. blurred vision
  3. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  4. chest pain
  5. chills
  6. confusion
  7. decreased urine output
  8. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  9. fainting
  10. fast, pounding, or irregular heartbeat or pulse
  11. feeling of warmth
  12. feeling unusually cold
  13. headache
  14. increased thirst
  15. muscle pain or cramps
  16. nausea
  17. nervousness
  18. pounding in the ears
  19. redness of the face, neck, arms, and occasionally, upper chest
  20. seizures
  21. shakiness in the legs, arms, hands, or feet
  22. shivering
  23. sweating
  24. swelling of the face, ankles, or hands
  25. trembling or shaking of the hands or feet
  26. unusual tiredness or weakness
  27. vomiting

Less common

  1. Bleeding gums
  2. bloody nose
  3. cough
  4. coughing up blood
  5. difficulty with breathing or swallowing
  6. dizziness
  7. fever
  8. inability to speak
  9. increased menstrual flow or vaginal bleeding
  10. loss of consciousness
  11. low blood pressure or pulse
  12. lower back or side pain
  13. nosebleeds
  14. pain in the chest, groin, or legs, especially calves of the legs
  15. pain or discomfort in the arms, jaw, back, or neck
  16. painful or difficult urination
  17. pale skin
  18. paralysis
  19. prolonged bleeding from cuts
  20. red or black, tarry stools
  21. red or dark brown urine
  22. severe constipation
  23. severe headaches of sudden onset
  24. severe numbness, especially on one side of the face or body
  25. slurred speech
  26. sore throat
  27. stomach pain, cramping, or burning
  28. sudden loss of coordination
  29. sudden onset of slurred speech
  30. sudden vision changes
  31. sweating
  32. temporary blindness
  33. ulcers, sores, or white spots in the mouth
  34. unusual bleeding or bruising
  35. vomiting of material that looks like coffee grounds, severe and continuing

Incidence not known

  1. Full feeling and pain in the upper abdomen
  2. nausea
  3. sudden weakness in the arms or legs
  4. sudden, severe chest pain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Diarrhea

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.